{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ma Y"],"funding":["MOST | National Natural Science Foundation of China (NSFC)","Tianjin Municipal Education Commission","Key laboratory of Marine Resource Chemistry and Food Technology, Ministry of Education","MOST | National Natural Science Foundation of China"],"pagination":["e0054024"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11267897"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["90(7)"],"pubmed_abstract":["Halophilic archaea are promising microbial cell factories for bacterioruberin (BR) production. BR is a natural product with multi-bioactivities, allowing potential application in many fields. In the previous work, a haloarchaeon <i>Halorubrum</i> sp. HRM-150 with a high proportion of BR (about 85%) was isolated, but the low yield impeded its large-scale production. This work figured out BR synthesis characteristics and mechanisms, and proposed strategies for yield improvement. First, glucose (10 g/L) and tryptone (15 g/L) were tested to be better sources for BR production. Besides, the combination of glucose and starch achieved the diauxic growth, and the biomass and BR productivity increased by 85% and 54% than using glucose. Additionally, this work first proposed the BR synthesis pattern"],"journal":["Applied and environmental microbiology"],"pubmed_title":["The biosynthesis mechanism of bacterioruberin in halophilic archaea revealed by genome and transcriptome analysis."],"pmcid":["PMC11267897"],"funding_grant_id":["42306106","2019KJ220","EMTUST-21-01"],"pubmed_authors":["Yang H","Xie W","Song M","Ma Y","Sui L","Zhang B","Sun Z"],"additional_accession":[]},"is_claimable":false,"name":"The biosynthesis mechanism of bacterioruberin in halophilic archaea revealed by genome and transcriptome analysis.","description":"Halophilic archaea are promising microbial cell factories for bacterioruberin (BR) production. BR is a natural product with multi-bioactivities, allowing potential application in many fields. In the previous work, a haloarchaeon <i>Halorubrum</i> sp. HRM-150 with a high proportion of BR (about 85%) was isolated, but the low yield impeded its large-scale production. This work figured out BR synthesis characteristics and mechanisms, and proposed strategies for yield improvement. First, glucose (10 g/L) and tryptone (15 g/L) were tested to be better sources for BR production. Besides, the combination of glucose and starch achieved the diauxic growth, and the biomass and BR productivity increased by 85% and 54% than using glucose. Additionally, this work first proposed the BR synthesis pattern","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jul","modification":"2026-06-01T19:46:36.149Z","creation":"2025-04-04T01:21:10.201Z"},"accession":"S-EPMC11267897","cross_references":{"pubmed":["38829054"],"doi":["10.1128/aem.00540-24"]}}