biostudies-literaturePisani SNational Institute for Health Research (NIHR)Parkinson&apos;s UKParkinson's UK1-10https://www.ebi.ac.uk/biostudies/studies/S-EPMC11268075biostudies-literatureUnknown27(1)<h4>Background</h4>Cognitive deficits are associated with poor quality of life and increased risk of development of dementia in patients with Parkinson's disease (PD) psychosis. The trajectory of cognitive decline in PD psychosis remains however unclear.<h4>Objective</h4>We examined this using data from the Parkinson's Progression Markers Initiative study.<h4>Methods</h4>We analysed data from patients with drug-naïve PD (n=676) and healthy controls (HC, n=187) over 5 years, and examined all cognitive measures assessed at each time point. We classified patients with PD into those who developed psychosis over the course of the study (PDP) and those without psychosis throughout (PDnP) using the Movement Disorders Society Unified Parkinson's Disease Rating Scale part I hallucinations/psychosisBMJ mental healthParkinson's disease psychosis associated with accelerated multidomain cognitive decline.PMC1126807516/126/53NIHR: EME 16/126/53I-1901Pisani SBhattacharyya SGosse LBallard CVelayudhan LAarsland DRay Chaudhuri KFfytche DfalseParkinson's disease psychosis associated with accelerated multidomain cognitive decline.<h4>Background</h4>Cognitive deficits are associated with poor quality of life and increased risk of development of dementia in patients with Parkinson's disease (PD) psychosis. The trajectory of cognitive decline in PD psychosis remains however unclear.<h4>Objective</h4>We examined this using data from the Parkinson's Progression Markers Initiative study.<h4>Methods</h4>We analysed data from patients with drug-naïve PD (n=676) and healthy controls (HC, n=187) over 5 years, and examined all cognitive measures assessed at each time point. We classified patients with PD into those who developed psychosis over the course of the study (PDP) and those without psychosis throughout (PDnP) using the Movement Disorders Society Unified Parkinson's Disease Rating Scale part I hallucinations/psychosis2024-01-01T00:00:00Z2024 Jul2026-06-01T06:51:08.169Z2025-04-19T13:12:59.445ZS-EPMC112680753904346510.1136/bmjment-2024-301062