{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Vilca SJ"],"funding":["NIDA NIH HHS","NCI NIH HHS","NINDS NIH HHS"],"pagination":["339-351"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11269013"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["120"],"pubmed_abstract":["Methamphetamine use disorder (MUD) is a chronic, relapsing disease that is characterized by repeated drug use despite negative consequences and for which there are currently no FDA-approved cessation therapeutics. Repeated methamphetamine (METH) use induces long-term gene expression changes in brain regions associated with reward processing and drug-seeking behavior, and recent evidence suggests that methamphetamine-induced neuroinflammation may also shape behavioral and molecular responses to the drug. Microglia, the resident immune cells in the brain, are principal drivers of neuroinflammatory responses and contribute to the pathophysiology of substance use disorders. Here, we investigated transcriptional and morphological changes in dorsal striatal microglia in response to methamphetami"],"journal":["Brain, behavior, and immunity"],"pubmed_title":["Microglia contribute to methamphetamine reinforcement and reflect persistent transcriptional and morphological adaptations to the drug."],"pmcid":["PMC11269013"],"funding_grant_id":["K01 DA045294","F30 DA060666","DP1 DA051828","U18 DA052533","F99 NS130871","R25 CA261632"],"pubmed_authors":["Bystrom LL","Margetts AV","Bourgain-Guglielmetti F","Hoglund L","Fleites I","Pollock TA","Tuesta LM","Vilca SJ","Wahlestedt C"],"additional_accession":[]},"is_claimable":false,"name":"Microglia contribute to methamphetamine reinforcement and reflect persistent transcriptional and morphological adaptations to the drug.","description":"Methamphetamine use disorder (MUD) is a chronic, relapsing disease that is characterized by repeated drug use despite negative consequences and for which there are currently no FDA-approved cessation therapeutics. Repeated methamphetamine (METH) use induces long-term gene expression changes in brain regions associated with reward processing and drug-seeking behavior, and recent evidence suggests that methamphetamine-induced neuroinflammation may also shape behavioral and molecular responses to the drug. Microglia, the resident immune cells in the brain, are principal drivers of neuroinflammatory responses and contribute to the pathophysiology of substance use disorders. Here, we investigated transcriptional and morphological changes in dorsal striatal microglia in response to methamphetami","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Aug","modification":"2026-06-01T07:15:57.233Z","creation":"2026-04-08T10:25:54.743Z"},"accession":"S-EPMC11269013","cross_references":{"pubmed":["38838836"],"doi":["10.1016/j.bbi.2024.05.038"]}}