{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Carrico AW"],"funding":["NIMH","NIDA NIH HHS","NIAID NIH HHS","NIMH NIH HHS","NIDA","NIAID"],"pagination":["151-158"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11269022"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["120"],"pubmed_abstract":["<h4>Objective</h4>This epigenomics sub-study embedded within a randomized controlled trial examined whether an evidenced-based behavioral intervention model that decreased stimulant use altered leukocyte DNA methylation (DNAm).<h4>Methods</h4>Sexual minority men with HIV who use methamphetamine were randomized to a five-session positive affect intervention (n = 32) or an attention-control condition (n = 21), both delivered during three months of contingency management for stimulant abstinence. All participants exhibited sustained HIV virologic control - an HIV viral load less than 40 copies/mL at baseline and six months post-randomization. The Illumina EPIC BeadChip measured leukocyte methylation of cytosine-phosphate-guanosine (CpG) sites mapping onto five a priori candidate genes of inte"],"journal":["Brain, behavior, and immunity"],"pubmed_title":["A positive affect intervention alters leukocyte DNA methylation in sexual minority men with HIV who use methamphetamine."],"pmcid":["PMC11269022"],"funding_grant_id":["K24-MH093225","K24 DA057874","P30 AI073961","K23-DA039800","P30 AI027763","K24 MH093225","R01 DA058437","R01 DA033854","R01-DA033854","K23 DA039800"],"pubmed_authors":["Moskowitz JT","Asam K","Ghanooni D","Aouizerat BE","Gouse H","Cherenack EM","Dilworth SE","Paul RH","Flentje A","Rubin LH","Neilands TB","Carrico AW","Fuchs D","Chavez JV"],"additional_accession":[]},"is_claimable":false,"name":"A positive affect intervention alters leukocyte DNA methylation in sexual minority men with HIV who use methamphetamine.","description":"<h4>Objective</h4>This epigenomics sub-study embedded within a randomized controlled trial examined whether an evidenced-based behavioral intervention model that decreased stimulant use altered leukocyte DNA methylation (DNAm).<h4>Methods</h4>Sexual minority men with HIV who use methamphetamine were randomized to a five-session positive affect intervention (n = 32) or an attention-control condition (n = 21), both delivered during three months of contingency management for stimulant abstinence. All participants exhibited sustained HIV virologic control - an HIV viral load less than 40 copies/mL at baseline and six months post-randomization. The Illumina EPIC BeadChip measured leukocyte methylation of cytosine-phosphate-guanosine (CpG) sites mapping onto five a priori candidate genes of inte","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Aug","modification":"2026-03-18T13:30:01.005Z","creation":"2025-08-18T09:54:17.984Z"},"accession":"S-EPMC11269022","cross_references":{"pubmed":["38777283"],"doi":["10.1016/j.bbi.2024.05.025"]}}