biostudies-literatureLang YGuangdong Provincial Natural Science FoundationNational Natural Science Foundation of China110205https://www.ebi.ac.uk/biostudies/studies/S-EPMC11269928biostudies-literatureUnknown27(7)Monoacylglycerol acyltransferase-2 (MOGAT2), encodes MOGAT enzyme in the re-synthesis of triacylglycerol and protects from metabolism disorders. While, its precise involvement in colorectal cancer (CRC) progression remains inadequately understood. Our study demonstrated that knockout of Mogat2 in Apc^min/+ mice expedited intestinal tumor growth and progression, indicating that Mogat2 plays a tumor-suppressing role in CRC. Mechanically, Mogat2 deletion resulted in a significant alter the gut microbiota, while Fecal Microbiota Transplantation (FMT) experiments demonstrated that the gut microbiota in Mogat2 deleted mice promoted tumor growth. Furthermore, we identified Mogat2 as a functional regulator suppressing CRC cell proliferation and tumor growth by inhibiting the NF-κB signaliScienceMonoacylglycerol acyltransferase-2 inhibits colorectal carcinogenesis in APC^min+/- mice.PMC1126992881972301KY013915819024732024A15150128008207322082172815Qiu JZhong CQian CDing LNiu YGuo LLiu ZZuo DChen XLi BLang YHuang BYuan YfalseMonoacylglycerol acyltransferase-2 inhibits colorectal carcinogenesis in APC^min+/- mice.Monoacylglycerol acyltransferase-2 (MOGAT2), encodes MOGAT enzyme in the re-synthesis of triacylglycerol and protects from metabolism disorders. While, its precise involvement in colorectal cancer (CRC) progression remains inadequately understood. Our study demonstrated that knockout of Mogat2 in Apc^min/+ mice expedited intestinal tumor growth and progression, indicating that Mogat2 plays a tumor-suppressing role in CRC. Mechanically, Mogat2 deletion resulted in a significant alter the gut microbiota, while Fecal Microbiota Transplantation (FMT) experiments demonstrated that the gut microbiota in Mogat2 deleted mice promoted tumor growth. Furthermore, we identified Mogat2 as a functional regulator suppressing CRC cell proliferation and tumor growth by inhibiting the NF-κB signal2024-01-01T00:00:00Z2024 Jul2026-03-27T16:51:23.858Z2025-08-27T03:11:14.304ZS-EPMC112699283905592810.1016/j.isci.2024.110205