{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lu J"],"funding":["Wu Jieping Medical Foundation","National Natural Science Foundation of China","National Key Research and Development Program of China"],"pagination":["375"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11270788"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["22(1)"],"pubmed_abstract":["<h4>Background</h4>Olanzapine (OLZ) reverses chronic stress-induced anxiety. Chronic stress promotes cancer development via abnormal neuro-endocrine activation. However, how intervention of brain-body interaction reverses chronic stress-induced tumorigenesis remains elusive.<h4>Methods</h4>Kras<sup>LSL-G12D/WT</sup> lung cancer model and LLC1 syngeneic tumor model were used to study the effect of OLZ on cancer stemness and anxiety-like behaviors. Cancer stemness was evaluated by qPCR, western-blotting, immunohistology staining and flow-cytometry analysis of stemness markers, and cancer stem-like function was assessed by serial dilution tumorigenesis in mice and extreme limiting dilution analysis in primary tumor cells. Anxiety-like behaviors in mice were detected by elevated plus maze and "],"journal":["Cell communication and signaling : CCS"],"pubmed_title":["Olanzapine suppresses mPFC activity-norepinephrine releasing to alleviate CLOCK-enhanced cancer stemness under chronic stress."],"pmcid":["PMC11270788"],"funding_grant_id":["No. 82373096","2023HZ060","2022YFA1104002","No. 82273480"],"pubmed_authors":["Wang C","Meng P","Kelley KW","Liu Q","Su K","Lv D","Luo H","Zhao Z","Wang L","Liu X","Peng F","Yang Y","Lu J","Zhang X","Liu C","Wang X","He B","Cui B"],"additional_accession":[]},"is_claimable":false,"name":"Olanzapine suppresses mPFC activity-norepinephrine releasing to alleviate CLOCK-enhanced cancer stemness under chronic stress.","description":"<h4>Background</h4>Olanzapine (OLZ) reverses chronic stress-induced anxiety. Chronic stress promotes cancer development via abnormal neuro-endocrine activation. However, how intervention of brain-body interaction reverses chronic stress-induced tumorigenesis remains elusive.<h4>Methods</h4>Kras<sup>LSL-G12D/WT</sup> lung cancer model and LLC1 syngeneic tumor model were used to study the effect of OLZ on cancer stemness and anxiety-like behaviors. Cancer stemness was evaluated by qPCR, western-blotting, immunohistology staining and flow-cytometry analysis of stemness markers, and cancer stem-like function was assessed by serial dilution tumorigenesis in mice and extreme limiting dilution analysis in primary tumor cells. Anxiety-like behaviors in mice were detected by elevated plus maze and ","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jul","modification":"2026-06-01T09:03:03.739Z","creation":"2025-08-31T03:04:52.327Z"},"accession":"S-EPMC11270788","cross_references":{"pubmed":["39054537"],"doi":["10.1186/s12964-024-01747-y"]}}