{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Harris SM"],"funding":["National Institute of Environmental Health Sciences","National Center for Advancing Translational Sciences","Michigan Institute for Clinical and Health Research","Eunice Kennedy Shriver National Institute of Child Health and Human Development","NCATS NIH HHS","NICHD NIH HHS","National Institute of Diabetes and Digestive and Kidney Diseases","NIDDK NIH HHS","NIEHS NIH HHS","National Institutes of Health"],"pagination":["117-125"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11270901"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["145"],"pubmed_abstract":["<h4>Introduction</h4>Hematopoietic stem cells are cells that differentiate into blood cell types. Although the placenta secretes hormones, proteins and other factors important for maternal/fetal health, cross-talk between placental and hematopoietic stem cells is poorly understood. Moreover, toxicant impacts on placental-hematopoietic stem cell communication is understudied. The goals of this study were to determine if factors secreted from placental cells alter transcriptomic responses in hematopoietic stem cells and if monoethylhexyl phthalate (MEHP), the bioactive metabolite of the pollutant diethylhexyl phthalate, modifies these effects.<h4>Methods</h4>We used K-562 and BeWo cells as in vitro models of hematopoietic stem cells and placental syncytiotrophoblasts, respectively. We treate"],"journal":["Placenta"],"pubmed_title":["Placental cell conditioned media modifies hematopoietic stem cell transcriptome invitro."],"pmcid":["PMC11270901"],"funding_grant_id":["P30 ES017885","R01 ES007062","UL1 TR002240","P42 ES017198","T32 DK071212","T32 ES007062","T32 HD079342","T32HD079342"],"pubmed_authors":["Loch-Caruso R","Bakulski KM","Elkin ER","Dou JF","Harris SM","Jaber S","Su AL"],"additional_accession":[]},"is_claimable":false,"name":"Placental cell conditioned media modifies hematopoietic stem cell transcriptome invitro.","description":"<h4>Introduction</h4>Hematopoietic stem cells are cells that differentiate into blood cell types. Although the placenta secretes hormones, proteins and other factors important for maternal/fetal health, cross-talk between placental and hematopoietic stem cells is poorly understood. Moreover, toxicant impacts on placental-hematopoietic stem cell communication is understudied. The goals of this study were to determine if factors secreted from placental cells alter transcriptomic responses in hematopoietic stem cells and if monoethylhexyl phthalate (MEHP), the bioactive metabolite of the pollutant diethylhexyl phthalate, modifies these effects.<h4>Methods</h4>We used K-562 and BeWo cells as in vitro models of hematopoietic stem cells and placental syncytiotrophoblasts, respectively. We treate","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jan","modification":"2026-04-08T19:45:09.791Z","creation":"2026-04-08T14:25:44.464Z"},"accession":"S-EPMC11270901","cross_references":{"pubmed":["38128222"],"doi":["10.1016/j.placenta.2023.12.016"]}}