{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Geiger CJ"],"funding":["HHS | National Institutes of Health","HHS | National Institutes of Health (NIH)","NIAID NIH HHS"],"pagination":["e0044223"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11270903"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["206(7)"],"pubmed_abstract":["Most microbial cells found in nature exist in matrix-covered, surface-attached communities known as biofilms. This mode of growth is initiated by the ability of the microbe to sense a surface on which to grow. The opportunistic pathogen <i>Pseudomonas aeruginosa</i> (<i>Pa</i>) PA14 utilizes a single polar flagellum and type 4 pili (T4P) to sense surfaces. For <i>Pa</i>, T4P-dependent \"twitching\" motility is characterized by effectively pulling the cell across a surface through a complex process of cooperative binding, pulling, and unbinding. T4P retraction is powered by hexameric ATPases. <i>Pa</i> cells that have engaged a surface increase production of the second messenger cyclic AMP (cAMP) over multiple generations via the Pil-Chp system. This rise in cAMP allows cells and their progen"],"journal":["Journal of bacteriology"],"pubmed_title":["A bacterial sense of touch: T4P retraction motor as a means of surface sensing by &lt;i&gt;Pseudomonas aeruginosa&lt;/i&gt; PA14."],"pmcid":["PMC11270903"],"funding_grant_id":["T32 AI007519","R01 AI143730","R37 AI052453, R01AI143730","R01 AI052453","R37 AI052453","R37 AI083256"],"pubmed_authors":["O'Toole GA","Geiger CJ","Wong GCL"],"additional_accession":[]},"is_claimable":false,"name":"A bacterial sense of touch: T4P retraction motor as a means of surface sensing by &lt;i&gt;Pseudomonas aeruginosa&lt;/i&gt; PA14.","description":"Most microbial cells found in nature exist in matrix-covered, surface-attached communities known as biofilms. This mode of growth is initiated by the ability of the microbe to sense a surface on which to grow. The opportunistic pathogen <i>Pseudomonas aeruginosa</i> (<i>Pa</i>) PA14 utilizes a single polar flagellum and type 4 pili (T4P) to sense surfaces. For <i>Pa</i>, T4P-dependent \"twitching\" motility is characterized by effectively pulling the cell across a surface through a complex process of cooperative binding, pulling, and unbinding. T4P retraction is powered by hexameric ATPases. <i>Pa</i> cells that have engaged a surface increase production of the second messenger cyclic AMP (cAMP) over multiple generations via the Pil-Chp system. This rise in cAMP allows cells and their progen","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jul","modification":"2026-06-03T00:59:46.094Z","creation":"2025-04-04T01:57:50.642Z"},"accession":"S-EPMC11270903","cross_references":{"pubmed":["38832786"],"doi":["10.1128/jb.00442-23"]}}