biostudies-literatureBermingham KMNIDDK NIH HHSMedical Research CouncilZOE Ltd1888-1897https://www.ebi.ac.uk/biostudies/studies/S-EPMC11271409biostudies-literatureUnknown30(7)Large variability exists in people's responses to foods. However, the efficacy of personalized dietary advice for health remains understudied. We compared a personalized dietary program (PDP) versus general advice (control) on cardiometabolic health using a randomized clinical trial. The PDP used food characteristics, individual postprandial glucose and triglyceride (TG) responses to foods, microbiomes and health history, to produce personalized food scores in an 18-week app-based program. The control group received standard care dietary advice (US Department of Agriculture Guidelines for Americans, 2020-2025) using online resources, check-ins, video lessons and a leaflet. Primary outcomes were serum low-density lipoprotein cholesterol and TG concentrations at baseline and at 18 weeks. ParNature medicineEffects of a personalized nutrition program on cardiometabolic health: a randomized controlled trial.PMC11271409MR/Y010175/1P30 DK111022MR/W026813/1Segata NBermingham KMArre ABulsiewicz WJValdes AMCapdevila JHadjigeorgiou GDelahanty LMPolidori LGardner CDAsnicar FDavies RLinenberg IBadri FBerry SEHall WLSpector TDWolf JOrdovas JMBernard HfalseEffects of a personalized nutrition program on cardiometabolic health: a randomized controlled trial.Large variability exists in people's responses to foods. However, the efficacy of personalized dietary advice for health remains understudied. We compared a personalized dietary program (PDP) versus general advice (control) on cardiometabolic health using a randomized clinical trial. The PDP used food characteristics, individual postprandial glucose and triglyceride (TG) responses to foods, microbiomes and health history, to produce personalized food scores in an 18-week app-based program. The control group received standard care dietary advice (US Department of Agriculture Guidelines for Americans, 2020-2025) using online resources, check-ins, video lessons and a leaflet. Primary outcomes were serum low-density lipoprotein cholesterol and TG concentrations at baseline and at 18 weeks. Par2024-01-01T00:00:00Z2024 Jul2026-06-02T23:12:21.539Z2025-04-19T13:12:24.614ZS-EPMC112714093871489810.1038/s41591-024-02951-6