biostudies-literatureUnknown10(1)Cole JBiological signal transduction networks are central to information processing and regulation of gene expression across all domains of life. Dysregulation is known to cause a wide array of diseases, including cancers. Here I introduce self-consistent signal transduction analysis, which utilizes genome-scale -omics data (specifically transcriptomics and/or proteomics) in order to predict the flow of information through these networks in an individualized manner. I apply the method to the study of endocrine therapy in breast cancer patients, and show that drugs that inhibit estrogen receptor α elicit a wide array of antitumoral effects, and that their most clinically-impactful ones are through the modulation of proliferative signals that control the genes GREB1, HK1, AKT1, MAPK1, AKT2, and NQNPJ systems biology and applications78https://www.ebi.ac.uk/biostudies/studies/S-EPMC11271576biostudies-literatureSelf-consistent signal transduction analysis for modeling context-specific signaling cascades and perturbations.PMC11271576Cole JfalseSelf-consistent signal transduction analysis for modeling context-specific signaling cascades and perturbations.Biological signal transduction networks are central to information processing and regulation of gene expression across all domains of life. Dysregulation is known to cause a wide array of diseases, including cancers. Here I introduce self-consistent signal transduction analysis, which utilizes genome-scale -omics data (specifically transcriptomics and/or proteomics) in order to predict the flow of information through these networks in an individualized manner. I apply the method to the study of endocrine therapy in breast cancer patients, and show that drugs that inhibit estrogen receptor α elicit a wide array of antitumoral effects, and that their most clinically-impactful ones are through the modulation of proliferative signals that control the genes GREB1, HK1, AKT1, MAPK1, AKT2, and NQ2024-01-01T00:00:00Z2024 Jul2026-06-01T10:01:13.646Z2025-04-19T13:12:14.915ZS-EPMC112715763903025810.1038/s41540-024-00404-x