biostudies-literatureLi WKey Research and Development Program of Zhejiang ProvinceNational Natural Science Foundation of ChinaZhejiang Province Natural Science FoundationNIHNIGMS NIH HHS240-257https://www.ebi.ac.uk/biostudies/studies/S-EPMC11271712biostudies-literatureUnknown17(2)Rice production accounts for approximately half of the freshwater resources utilized in agriculture, resulting in greenhouse gas emissions such as methane (CH₄) from flooded paddy fields. To address this challenge, environmentally friendly and cost-effective water-saving techniques have become widely adopted in rice cultivation. However, the implementation of water-saving treatments (WSTs) in paddy-field rice has been associated with a substantial yield loss of up to 50% as well as a reduction in nitrogen use efficiency (NUE). In this study, we discovered that the target of rapamycin (TOR) signaling pathway is compromised in rice under WST. Polysome profiling-coupled transcriptome sequencing (polysome-seq) analysis unveiled a substantial reduction in global translation in responMolecular plantMitigating growth-stress tradeoffs via elevated TOR signaling in rice.PMC11271712R01 GM129093Liu JZhang JZheng PTu JLi WTao ZLi ZFang ZHuang YZhang YYe RHu HChen WSong SDu HPan RYuan YSheen JfalseMitigating growth-stress tradeoffs via elevated TOR signaling in rice.Rice production accounts for approximately half of the freshwater resources utilized in agriculture, resulting in greenhouse gas emissions such as methane (CH₄) from flooded paddy fields. To address this challenge, environmentally friendly and cost-effective water-saving techniques have become widely adopted in rice cultivation. However, the implementation of water-saving treatments (WSTs) in paddy-field rice has been associated with a substantial yield loss of up to 50% as well as a reduction in nitrogen use efficiency (NUE). In this study, we discovered that the target of rapamycin (TOR) signaling pathway is compromised in rice under WST. Polysome profiling-coupled transcriptome sequencing (polysome-seq) analysis unveiled a substantial reduction in global translation in respon2024-01-01T00:00:00Z2024 Feb2025-04-05T11:34:02.922Z2025-04-05T11:34:02.922ZS-EPMC112717123805333710.1016/j.molp.2023.12.002