{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Guitor AK"],"funding":["McMaster University","Cisco Systems Canada","Grand Challenges Canada","Hewlett Packard Enterprise","CIHR","bioMérieux","Pure Storage"],"pagination":["239-249"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11272098"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["230(1)"],"pubmed_abstract":["<h4>Background</h4>Macrolide antibiotics, including azithromycin, can reduce under 5 years of age mortality rates and treat various infections in children in sub-Saharan Africa. These exposures, however, can select for antibiotic-resistant bacteria in the gut microbiota.<h4>Methods</h4>Our previous randomized controlled trial (RCT) of a rapid-test-and-treat strategy for severe acute diarrheal disease in children in Botswana included an intervention (3-day azithromycin dose) group and a control group that received supportive treatment. In this prospective matched cohort study using stools collected at baseline and 60 days after treatment from RCT participants, the collection of antibiotic resistance genes or resistome was compared between groups.<h4>Results</h4>Certain macrolide resistance "],"journal":["The Journal of infectious diseases"],"pubmed_title":["Minimal Impact on the Resistome of Children in Botswana After Azithromycin Treatment for Acute Severe Diarrheal Disease."],"pmcid":["PMC11272098"],"funding_grant_id":["GSD-164145"],"pubmed_authors":["Mokomane M","Goldfarb DM","Lechiile K","McArthur AG","Guitor AK","Katyukhina A","Pernica JM","Wright GD"],"additional_accession":[]},"is_claimable":false,"name":"Minimal Impact on the Resistome of Children in Botswana After Azithromycin Treatment for Acute Severe Diarrheal Disease.","description":"<h4>Background</h4>Macrolide antibiotics, including azithromycin, can reduce under 5 years of age mortality rates and treat various infections in children in sub-Saharan Africa. These exposures, however, can select for antibiotic-resistant bacteria in the gut microbiota.<h4>Methods</h4>Our previous randomized controlled trial (RCT) of a rapid-test-and-treat strategy for severe acute diarrheal disease in children in Botswana included an intervention (3-day azithromycin dose) group and a control group that received supportive treatment. In this prospective matched cohort study using stools collected at baseline and 60 days after treatment from RCT participants, the collection of antibiotic resistance genes or resistome was compared between groups.<h4>Results</h4>Certain macrolide resistance ","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jul","modification":"2026-04-08T18:36:09.468Z","creation":"2025-04-05T19:21:07.592Z"},"accession":"S-EPMC11272098","cross_references":{"pubmed":["39052715"],"doi":["10.1093/infdis/jiae049"]}}