{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Malouli D"],"funding":["Bill and Melinda Gates Foundation (Bill & Melinda Gates Foundation)","Bill and Melinda Gates Foundation","NIH HHS"],"pagination":["6007"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11272155"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(1)"],"pubmed_abstract":["An influenza vaccine approach that overcomes the problem of viral sequence diversity and provides long-lived heterosubtypic protection is urgently needed to protect against pandemic influenza viruses. Here, to determine if lung-resident effector memory T cells induced by cytomegalovirus (CMV)-vectored vaccines expressing conserved internal influenza antigens could protect against lethal influenza challenge, we immunize Mauritian cynomolgus macaques (MCM) with cynomolgus CMV (CyCMV) vaccines expressing H1N1 1918 influenza M1, NP, and PB1 antigens (CyCMV/Flu), and challenge with heterologous, aerosolized avian H5N1 influenza. All six unvaccinated MCM died by seven days post infection with acute respiratory distress, while 54.5% (6/11) CyCMV/Flu-vaccinated MCM survived. Survival correlates wi"],"journal":["Nature communications"],"pubmed_title":["Cytomegalovirus vaccine vector-induced effector memory CD4 + T cells protect cynomolgus macaques from lethal aerosolized heterologous avian influenza challenge."],"pmcid":["PMC11272155"],"funding_grant_id":["P51 OD011104","OPP1213553","P51 OD011092","P51 OD010425"],"pubmed_authors":["Treaster L","Wallace M","Yun G","Maness NJ","Hughes CM","Selseth A","Williams C","Dufour JP","Morrow DW","Castanha P","Picker LJ","Gale M","Barratt-Boyes S","Laughlin A","Whitmore LS","Lundy J","Fruh K","Penney T","Midgett M","Tisoncik-Go J","Papen CR","Yu Y","Reed DS","Malouli D","Gilbride RM","Taher H","Schiro F","Reed J","Hansen SG","Aye PP","Yeung Y","Gao L","Sacha JB","Tiwary M"],"additional_accession":[]},"is_claimable":false,"name":"Cytomegalovirus vaccine vector-induced effector memory CD4 + T cells protect cynomolgus macaques from lethal aerosolized heterologous avian influenza challenge.","description":"An influenza vaccine approach that overcomes the problem of viral sequence diversity and provides long-lived heterosubtypic protection is urgently needed to protect against pandemic influenza viruses. Here, to determine if lung-resident effector memory T cells induced by cytomegalovirus (CMV)-vectored vaccines expressing conserved internal influenza antigens could protect against lethal influenza challenge, we immunize Mauritian cynomolgus macaques (MCM) with cynomolgus CMV (CyCMV) vaccines expressing H1N1 1918 influenza M1, NP, and PB1 antigens (CyCMV/Flu), and challenge with heterologous, aerosolized avian H5N1 influenza. All six unvaccinated MCM died by seven days post infection with acute respiratory distress, while 54.5% (6/11) CyCMV/Flu-vaccinated MCM survived. Survival correlates wi","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jul","modification":"2026-06-01T06:50:08.383Z","creation":"2025-04-19T13:12:10.402Z"},"accession":"S-EPMC11272155","cross_references":{"pubmed":["39030218"],"doi":["10.1038/s41467-024-50345-6"]}}