{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wu Y"],"funding":["Intramural NIH HHS","William and Ella Owens Medical Research Foundation, and National Cancer Institute","NIDDK NIH HHS","National Institute of Diabetes and Digestive and Kidney Diseases","NCI NIH HHS","CPRIT Research Training","National Cancer Institute of the United States","Cancer Prevention and Research Institute of Texas"],"pagination":["e84532"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11272159"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13"],"pubmed_abstract":["The Hippo pathway plays a central role in tissue development and homeostasis. However, the function of Hippo in pancreatic endocrine development remains obscure. Here, we generated novel conditional genetically engineered mouse models to examine the roles of Hippo pathway-mediated YAP1/TAZ inhibition in the development stages of endocrine specification and differentiation. While YAP1 protein was localized to the nuclei in bipotent progenitor cells, Neurogenin 3 expressing endocrine progenitors completely lost YAP1 expression. Using genetically engineered mouse models, we found that inactivation of YAP1 requires both an intact Hippo pathway and Neurogenin 3 protein. Gene deletion of Lats1 and 2 kinases (<i>Lats1&2</i>) in endocrine progenitor cells of developing mouse pancreas using <i>Neur"],"journal":["eLife"],"pubmed_title":["Hippo pathway-mediated YAP1/TAZ inhibition is essential for proper pancreatic endocrine specification and differentiation."],"pmcid":["PMC11272159"],"funding_grant_id":["R01DK110361","R1219","RP140105","ZIA BC011798","RP170345","P30 CA054174","R01 CA237159","R01 DK110361","R21 CA218968"],"pubmed_authors":["Yin X","Luan Y","Liu J","Nipper MH","Arda HE","Vo T","Qin K","Deng J","Ramjit LR","Ye Z","Lopez KM","Wang P","Rajhans S","Wu Y","Xu Y"],"additional_accession":[]},"is_claimable":false,"name":"Hippo pathway-mediated YAP1/TAZ inhibition is essential for proper pancreatic endocrine specification and differentiation.","description":"The Hippo pathway plays a central role in tissue development and homeostasis. However, the function of Hippo in pancreatic endocrine development remains obscure. Here, we generated novel conditional genetically engineered mouse models to examine the roles of Hippo pathway-mediated YAP1/TAZ inhibition in the development stages of endocrine specification and differentiation. While YAP1 protein was localized to the nuclei in bipotent progenitor cells, Neurogenin 3 expressing endocrine progenitors completely lost YAP1 expression. Using genetically engineered mouse models, we found that inactivation of YAP1 requires both an intact Hippo pathway and Neurogenin 3 protein. Gene deletion of Lats1 and 2 kinases (<i>Lats1&2</i>) in endocrine progenitor cells of developing mouse pancreas using <i>Neur","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jul","modification":"2026-06-02T23:34:45.166Z","creation":"2026-04-21T03:17:04.38Z"},"accession":"S-EPMC11272159","cross_references":{"pubmed":["39051998"],"doi":["10.7554/eLife.84532"]}}