{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["45(8)"],"submitter":["Xia LX"],"pubmed_abstract":["Cardiopulmonary progenitor cells (CPPs) constitute a minor subpopulation of cells that are commonly associated with heart and lung morphogenesis during embryonic development but completely subside after birth. This fact offers the possibility for the treatment of pulmonary heart disease (PHD), in which the lung and heart are both damaged. A reliable source of CPPs is urgently needed. In this study, we reprogrammed human cardiac fibroblasts (HCFs) into CPP-like cells (or induced CPPs, iCPPs) and evaluated the therapeutic potential of iCPP-derived exosomes for acute lung injury (ALI). iCPPs were created in passage 3 primary HCFs by overexpressing GLI1, WNT2, ISL1 and TBX5 (GWIT). Exosomes were isolated from the culture medium of passage 6-8 GWIT-iCPPs. A mouse ALI model was established by in"],"journal":["Acta pharmacologica Sinica"],"pagination":["1644-1659"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11272782"],"repository":["biostudies-literature"],"pubmed_title":["Exosomes derived from induced cardiopulmonary progenitor cells alleviate acute lung injury in mice."],"pmcid":["PMC11272782"],"pubmed_authors":["Huang LJ","Xia LX","Zhao LX","Zhu YG","Tao H","Pan QR","Yang XY","Jiang WJ","Li Z","Qin JF","Xiao YY","Mandukhail SR","Yu XY"],"additional_accession":[]},"is_claimable":false,"name":"Exosomes derived from induced cardiopulmonary progenitor cells alleviate acute lung injury in mice.","description":"Cardiopulmonary progenitor cells (CPPs) constitute a minor subpopulation of cells that are commonly associated with heart and lung morphogenesis during embryonic development but completely subside after birth. This fact offers the possibility for the treatment of pulmonary heart disease (PHD), in which the lung and heart are both damaged. A reliable source of CPPs is urgently needed. In this study, we reprogrammed human cardiac fibroblasts (HCFs) into CPP-like cells (or induced CPPs, iCPPs) and evaluated the therapeutic potential of iCPP-derived exosomes for acute lung injury (ALI). iCPPs were created in passage 3 primary HCFs by overexpressing GLI1, WNT2, ISL1 and TBX5 (GWIT). Exosomes were isolated from the culture medium of passage 6-8 GWIT-iCPPs. A mouse ALI model was established by in","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Aug","modification":"2026-03-18T13:34:43.684Z","creation":"2025-08-18T09:54:21.831Z"},"accession":"S-EPMC11272782","cross_references":{"pubmed":["38589686"],"doi":["10.1038/s41401-024-01253-4"]}}