biostudies-literatureUnknown24(2)Tebaldi MBoston Scientific<h4>Background</h4>Recently, questions around the efficacy and effectiveness of Fractional Flow Reserve (FFR) have arisen in various clinical settings.<h4>Methods</h4>The Clinical Outcome of FFR-guided Revascularization Strategy of Coronary Lesions (HALE-BOPP) study is an investigator-initiated, multicentre, international prospective study enrolling patients who underwent FFR measurement on at least one vessel. In accordance with the decision-making workflow and treatment, the vessels were classified in three subgroups: (i) angio-revascularized, (ii) FFR-revascularized, (iii) FFR-deferred. The primary endpoint was the occurrence of target vessel failure (TVF, cardiac death, target vessel myocardial infarction and ischemia-driven target vessel revascularization). The analysis was carried ouReviews in cardiovascular medicine62https://www.ebi.ac.uk/biostudies/studies/S-EPMC11273154biostudies-literatureClinical Outcome of FFR-Guided Revascularization Strategy of Coronary Lesions: The HALE-BOPP Study.PMC11273154Tedeschi DCortese BPompei GGibiino FDurante AIelasi AArena MMarrone ABarbato EWatkins SScala ATebaldi MGallo FPavasini RSerenelli MCampo GCaglioni SScollo EBiscaglia SMele DVerdoliva SScoccia AD'Aniello EValentini GBilotta FfalseClinical Outcome of FFR-Guided Revascularization Strategy of Coronary Lesions: The HALE-BOPP Study.<h4>Background</h4>Recently, questions around the efficacy and effectiveness of Fractional Flow Reserve (FFR) have arisen in various clinical settings.<h4>Methods</h4>The Clinical Outcome of FFR-guided Revascularization Strategy of Coronary Lesions (HALE-BOPP) study is an investigator-initiated, multicentre, international prospective study enrolling patients who underwent FFR measurement on at least one vessel. In accordance with the decision-making workflow and treatment, the vessels were classified in three subgroups: (i) angio-revascularized, (ii) FFR-revascularized, (iii) FFR-deferred. The primary endpoint was the occurrence of target vessel failure (TVF, cardiac death, target vessel myocardial infarction and ischemia-driven target vessel revascularization). The analysis was carried ou2023-01-01T00:00:00Z2023 Feb2026-04-08T15:25:15.061Z2026-04-08T04:31:19.376ZS-EPMC112731543907742110.31083/j.rcm2402062