{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Shen Z"],"funding":["CAMS Innovation Fund for Medical Sciences","National Natural Science Foundation of China","the Fundamental Research Funds for the Central public welfare research institutes"],"pagination":["803"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11273404"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(7)"],"pubmed_abstract":["Pregabalin is a medication primarily used in the treatment of neuropathic pain and anxiety disorders, owing to its gabapentinoid properties. Pregabalin monotherapy faces limitations due to its variable efficacy and dose-dependent adverse reactions. In this study, we conducted a comprehensive investigation into the potentiation of pregabalin's analgesic effects by dexborneol, a neuroprotective bicyclic monoterpenoid compound. We performed animal experiments where pain models were induced using two methods: peripheral nerve injury, involving axotomy and ligation of the tibial and common peroneal nerves, and incisional pain through a longitudinal incision in the hind paw, while employing a multifaceted methodology that integrates behavioral pharmacology, molecular biology, neuromorphology, an"],"journal":["Antioxidants (Basel, Switzerland)"],"pubmed_title":["Dexborneol Amplifies Pregabalin's Analgesic Effect in Mouse Models of Peripheral Nerve Injury and Incisional Pain."],"pmcid":["PMC11273404"],"funding_grant_id":["ZZ-JQ2023008","2022-I2M-1-016","82374061"],"pubmed_authors":["Guo YD","Tie C","Zhou P","Tang MZ","Han YX","Shen HR","Gao TL","Shen Z","Li T","Jiang W","Jiang JD","Su YX","Cui JJ"],"additional_accession":[]},"is_claimable":false,"name":"Dexborneol Amplifies Pregabalin's Analgesic Effect in Mouse Models of Peripheral Nerve Injury and Incisional Pain.","description":"Pregabalin is a medication primarily used in the treatment of neuropathic pain and anxiety disorders, owing to its gabapentinoid properties. Pregabalin monotherapy faces limitations due to its variable efficacy and dose-dependent adverse reactions. In this study, we conducted a comprehensive investigation into the potentiation of pregabalin's analgesic effects by dexborneol, a neuroprotective bicyclic monoterpenoid compound. We performed animal experiments where pain models were induced using two methods: peripheral nerve injury, involving axotomy and ligation of the tibial and common peroneal nerves, and incisional pain through a longitudinal incision in the hind paw, while employing a multifaceted methodology that integrates behavioral pharmacology, molecular biology, neuromorphology, an","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jul","modification":"2026-07-09T11:17:06.834Z","creation":"2026-07-09T10:43:55.861Z"},"accession":"S-EPMC11273404","cross_references":{"pubmed":["39061872"],"doi":["10.3390/antiox13070803"]}}