biostudies-literatureShen ZCAMS Innovation Fund for Medical SciencesNational Natural Science Foundation of Chinathe Fundamental Research Funds for the Central public welfare research institutes803https://www.ebi.ac.uk/biostudies/studies/S-EPMC11273404biostudies-literatureUnknown13(7)Pregabalin is a medication primarily used in the treatment of neuropathic pain and anxiety disorders, owing to its gabapentinoid properties. Pregabalin monotherapy faces limitations due to its variable efficacy and dose-dependent adverse reactions. In this study, we conducted a comprehensive investigation into the potentiation of pregabalin's analgesic effects by dexborneol, a neuroprotective bicyclic monoterpenoid compound. We performed animal experiments where pain models were induced using two methods: peripheral nerve injury, involving axotomy and ligation of the tibial and common peroneal nerves, and incisional pain through a longitudinal incision in the hind paw, while employing a multifaceted methodology that integrates behavioral pharmacology, molecular biology, neuromorphology, anAntioxidants (Basel, Switzerland)Dexborneol Amplifies Pregabalin's Analgesic Effect in Mouse Models of Peripheral Nerve Injury and Incisional Pain.PMC11273404ZZ-JQ20230082022-I2M-1-01682374061Guo YDTie CZhou PTang MZHan YXShen HRGao TLShen ZLi TJiang WJiang JDSu YXCui JJfalseDexborneol Amplifies Pregabalin's Analgesic Effect in Mouse Models of Peripheral Nerve Injury and Incisional Pain.Pregabalin is a medication primarily used in the treatment of neuropathic pain and anxiety disorders, owing to its gabapentinoid properties. Pregabalin monotherapy faces limitations due to its variable efficacy and dose-dependent adverse reactions. In this study, we conducted a comprehensive investigation into the potentiation of pregabalin's analgesic effects by dexborneol, a neuroprotective bicyclic monoterpenoid compound. We performed animal experiments where pain models were induced using two methods: peripheral nerve injury, involving axotomy and ligation of the tibial and common peroneal nerves, and incisional pain through a longitudinal incision in the hind paw, while employing a multifaceted methodology that integrates behavioral pharmacology, molecular biology, neuromorphology, an2024-01-01T00:00:00Z2024 Jul2026-07-09T11:17:06.834Z2026-07-09T10:43:55.861ZS-EPMC112734043906187210.3390/antiox13070803