{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Choi YJ"],"funding":["Korea Disease Control and Prevention Agency"],"pagination":["610"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11273472"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(7)"],"pubmed_abstract":["The spread of multidrug-resistant <i>Acinetobacter baumannii</i> in hospitals and nursing homes poses serious healthcare challenges. Therefore, we aimed to isolate and characterize lytic bacteriophages targeting carbapenem-resistant <i>Acinetobacter baumannii</i> (CRAB). Of the 21 isolated <i>A. baumannii</i> phages, 11 exhibited potent lytic activities against clinical isolates of CRAB. Based on host spectrum and RAPD-PCR results, 11 phages were categorized into four groups. Three phages (vB_AbaP_W8, vB_AbaSi_W9, and vB_AbaSt_W16) were further characterized owing to their antibacterial efficacy, morphology, and whole-genome sequence and were found to lyse 37.93%, 89.66%, and 37.93%, respectively, of the 29 tested CRAB isolates. The lytic spectrum of phages varied depending on the multiloc"],"journal":["Antibiotics (Basel, Switzerland)"],"pubmed_title":["Isolation and Characterization of Novel Bacteriophages to Target Carbapenem-Resistant <i>Acinetobacter baumannii</i>."],"pmcid":["PMC11273472"],"funding_grant_id":["2022-ER2202-00"],"pubmed_authors":["Kim S","Choi YJ","Shin M","Kim J"],"additional_accession":[]},"is_claimable":false,"name":"Isolation and Characterization of Novel Bacteriophages to Target Carbapenem-Resistant <i>Acinetobacter baumannii</i>.","description":"The spread of multidrug-resistant <i>Acinetobacter baumannii</i> in hospitals and nursing homes poses serious healthcare challenges. Therefore, we aimed to isolate and characterize lytic bacteriophages targeting carbapenem-resistant <i>Acinetobacter baumannii</i> (CRAB). Of the 21 isolated <i>A. baumannii</i> phages, 11 exhibited potent lytic activities against clinical isolates of CRAB. Based on host spectrum and RAPD-PCR results, 11 phages were categorized into four groups. Three phages (vB_AbaP_W8, vB_AbaSi_W9, and vB_AbaSt_W16) were further characterized owing to their antibacterial efficacy, morphology, and whole-genome sequence and were found to lyse 37.93%, 89.66%, and 37.93%, respectively, of the 29 tested CRAB isolates. The lytic spectrum of phages varied depending on the multiloc","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jun","modification":"2026-05-27T12:15:19.202Z","creation":"2025-04-19T13:11:06.378Z"},"accession":"S-EPMC11273472","cross_references":{"pubmed":["39061292"],"doi":["10.3390/antibiotics13070610"]}}