{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Neves R"],"funding":["College of Radiographers","Action for A-T"],"pagination":["e70049"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11273546"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(14)"],"pubmed_abstract":["<h4>Background/objectives</h4>Ataxia telangiectasia (A-T) is an inherited multisystem disorder with increased sensitivity to ionising radiation and elevated cancer risk. Although other cancer predisposition syndromes have established cancer screening protocols, evidence-based guidelines for cancer screening in A-T are lacking. This study sought to assess feasibility of a cancer screening protocol based on whole-body MRI (WB-MRI) in children and young people with A-T.<h4>Design/methods</h4>Children and young people with A-T were invited to undergo a one-off non-sedated 3-Tesla WB-MRI. Completion rate of WB-MRI was recorded and diagnostic image quality assessed by two experienced radiologists, with pre-specified success thresholds for scan completion of >50% participants and image quality be"],"journal":["Cancer medicine"],"pubmed_title":["Feasibility of whole-body MRI for cancer screening in children and young people with ataxia telangiectasia: A mixed methods cross-sectional study."],"pmcid":["PMC11273546"],"funding_grant_id":["College of Radiographers / DF021","Action for A-T/20NOT05 (David Peake Fund)"],"pubmed_authors":["Fernandez NS","Dandapani M","Neves R","Panek R","Clarkson K","Wilne S","Glazebrook C","Panagioti O","Dineen RA","Whitehouse WP","Suri M","Jagani S"],"additional_accession":[]},"is_claimable":false,"name":"Feasibility of whole-body MRI for cancer screening in children and young people with ataxia telangiectasia: A mixed methods cross-sectional study.","description":"<h4>Background/objectives</h4>Ataxia telangiectasia (A-T) is an inherited multisystem disorder with increased sensitivity to ionising radiation and elevated cancer risk. Although other cancer predisposition syndromes have established cancer screening protocols, evidence-based guidelines for cancer screening in A-T are lacking. This study sought to assess feasibility of a cancer screening protocol based on whole-body MRI (WB-MRI) in children and young people with A-T.<h4>Design/methods</h4>Children and young people with A-T were invited to undergo a one-off non-sedated 3-Tesla WB-MRI. Completion rate of WB-MRI was recorded and diagnostic image quality assessed by two experienced radiologists, with pre-specified success thresholds for scan completion of >50% participants and image quality be","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jul","modification":"2026-04-21T03:28:44.31Z","creation":"2025-04-19T13:11:47.669Z"},"accession":"S-EPMC11273546","cross_references":{"pubmed":["39056567"],"doi":["10.1002/cam4.70049"]}}