biostudies-literatureNeves RCollege of RadiographersAction for A-Te70049https://www.ebi.ac.uk/biostudies/studies/S-EPMC11273546biostudies-literatureUnknown13(14)<h4>Background/objectives</h4>Ataxia telangiectasia (A-T) is an inherited multisystem disorder with increased sensitivity to ionising radiation and elevated cancer risk. Although other cancer predisposition syndromes have established cancer screening protocols, evidence-based guidelines for cancer screening in A-T are lacking. This study sought to assess feasibility of a cancer screening protocol based on whole-body MRI (WB-MRI) in children and young people with A-T.<h4>Design/methods</h4>Children and young people with A-T were invited to undergo a one-off non-sedated 3-Tesla WB-MRI. Completion rate of WB-MRI was recorded and diagnostic image quality assessed by two experienced radiologists, with pre-specified success thresholds for scan completion of >50% participants and image quality beCancer medicineFeasibility of whole-body MRI for cancer screening in children and young people with ataxia telangiectasia: A mixed methods cross-sectional study.PMC11273546College of Radiographers / DF021Action for A-T/20NOT05 (David Peake Fund)Fernandez NSDandapani MNeves RPanek RClarkson KWilne SGlazebrook CPanagioti ODineen RAWhitehouse WPSuri MJagani SfalseFeasibility of whole-body MRI for cancer screening in children and young people with ataxia telangiectasia: A mixed methods cross-sectional study.<h4>Background/objectives</h4>Ataxia telangiectasia (A-T) is an inherited multisystem disorder with increased sensitivity to ionising radiation and elevated cancer risk. Although other cancer predisposition syndromes have established cancer screening protocols, evidence-based guidelines for cancer screening in A-T are lacking. This study sought to assess feasibility of a cancer screening protocol based on whole-body MRI (WB-MRI) in children and young people with A-T.<h4>Design/methods</h4>Children and young people with A-T were invited to undergo a one-off non-sedated 3-Tesla WB-MRI. Completion rate of WB-MRI was recorded and diagnostic image quality assessed by two experienced radiologists, with pre-specified success thresholds for scan completion of >50% participants and image quality be2024-01-01T00:00:00Z2024 Jul2026-04-21T03:28:44.31Z2025-04-19T13:11:47.669ZS-EPMC112735463905656710.1002/cam4.70049