{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lin YC"],"funding":["National Science and Technology Council, Taiwan","National Science and Technology Council (NSTC), Taiwan","National Health Research Institute (NHRI), Taiwan"],"pagination":["826"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11273629"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(7)"],"pubmed_abstract":["Oxidative stress resulting from reactive oxygen species (ROS) is often considered to be the leading cause of interstitial cystitis (IC), which is a chronic inflammatory disease. Antioxidants have been proven to have promising therapeutic effects on IC. In this study, we present an antioxidant intervention for IC by introducing curcumin-loaded cerium oxide nanoparticles (Cur-CONPs). Recognizing oxidative stress as the primary contributor to IC, our research builds on previous work utilizing cerium oxide nanoparticles (CONPs) for their outstanding antioxidant and anti-inflammatory properties. However, given the need to effectively relieve acute inflammation, we engineered Cur-CONPs to harness the short-term radical-scavenging antioxidant prowess of curcumin. Through in vitro studies, we demo"],"journal":["Antioxidants (Basel, Switzerland)"],"pubmed_title":["Characterization and Therapeutic Potential of Curcumin-Loaded Cerium Oxide Nanoparticles for Interstitial Cystitis Management."],"pmcid":["PMC11273629"],"funding_grant_id":["BN-112-PP-01","111-2221-E-002-037-MY3"],"pubmed_authors":["Lin YC","Liu LJ","Lin FH","Zhang CH","Liang YJ"],"additional_accession":[]},"is_claimable":false,"name":"Characterization and Therapeutic Potential of Curcumin-Loaded Cerium Oxide Nanoparticles for Interstitial Cystitis Management.","description":"Oxidative stress resulting from reactive oxygen species (ROS) is often considered to be the leading cause of interstitial cystitis (IC), which is a chronic inflammatory disease. Antioxidants have been proven to have promising therapeutic effects on IC. In this study, we present an antioxidant intervention for IC by introducing curcumin-loaded cerium oxide nanoparticles (Cur-CONPs). Recognizing oxidative stress as the primary contributor to IC, our research builds on previous work utilizing cerium oxide nanoparticles (CONPs) for their outstanding antioxidant and anti-inflammatory properties. However, given the need to effectively relieve acute inflammation, we engineered Cur-CONPs to harness the short-term radical-scavenging antioxidant prowess of curcumin. Through in vitro studies, we demo","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jul","modification":"2026-06-30T03:11:07.647Z","creation":"2025-04-19T13:12:03.168Z"},"accession":"S-EPMC11273629","cross_references":{"pubmed":["39061895"],"doi":["10.3390/antiox13070826"]}}