{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Uziel O"],"funding":["The VARDA and BOAZ DOTAN RESEARCH CENTER at the Tel Aviv University","Dotan Grant of the CBRC, Tel Aviv University"],"pagination":["1381"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11273944"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(7)"],"pubmed_abstract":["We hypothesized that via extracellular vesicles (EVs), chronic lymphocytic leukemia (CLL) cells turn endothelial cells into CLL-supportive cells. To test this, we treated vein-derived (HUVECs) and artery-derived (HAOECs) endothelial cells with EVs isolated from the peripheral blood of 45 treatment-naïve patients. Endothelial cells took up CLL-EVs in a dose- and time-dependent manner. To test whether CLL-EVs turn endothelial cells into IL-6-producing cells, we exposed them to CLL-EVs and found a 50% increase in IL-6 levels. Subsequently, we filtered out the endothelial cells and added CLL cells to this IL-6-enriched medium. After 15 min, STAT3 became phosphorylated, and there was a 40% decrease in apoptosis rate, indicating that IL-6 activated the STAT3-dependent anti-apoptotic pathway. Pho"],"journal":["Biomedicines"],"pubmed_title":["Chronic Lymphocytic Leukemia (CLL)-Derived Extracellular Vesicles Educate Endothelial Cells to Become IL-6-Producing, CLL-Supportive Cells."],"pmcid":["PMC11273944"],"funding_grant_id":["none"],"pubmed_authors":["Uziel O","Sarsor Z","Sharan R","Raanani P","Kliminski V","Lahav M","Regev A","Bogen S","Gervits A","Beery E","Signorini LF","Rozovski U","Shimony S","Lipshtein L"],"additional_accession":[]},"is_claimable":false,"name":"Chronic Lymphocytic Leukemia (CLL)-Derived Extracellular Vesicles Educate Endothelial Cells to Become IL-6-Producing, CLL-Supportive Cells.","description":"We hypothesized that via extracellular vesicles (EVs), chronic lymphocytic leukemia (CLL) cells turn endothelial cells into CLL-supportive cells. To test this, we treated vein-derived (HUVECs) and artery-derived (HAOECs) endothelial cells with EVs isolated from the peripheral blood of 45 treatment-naïve patients. Endothelial cells took up CLL-EVs in a dose- and time-dependent manner. To test whether CLL-EVs turn endothelial cells into IL-6-producing cells, we exposed them to CLL-EVs and found a 50% increase in IL-6 levels. Subsequently, we filtered out the endothelial cells and added CLL cells to this IL-6-enriched medium. After 15 min, STAT3 became phosphorylated, and there was a 40% decrease in apoptosis rate, indicating that IL-6 activated the STAT3-dependent anti-apoptotic pathway. Pho","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jun","modification":"2026-07-09T11:10:28.683Z","creation":"2026-07-09T10:42:53.378Z"},"accession":"S-EPMC11273944","cross_references":{"pubmed":["39061955"],"doi":["10.3390/biomedicines12071381"]}}