{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Xian J"],"funding":["University of California System"],"pagination":["1573"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11274362"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(7)"],"pubmed_abstract":["Drs. John and Ford reported in <i>biomedicines</i> that a variant transcript encoding receptor tyrosine kinase-like orphan receptor 1 (ROR1), namely ENST00000545203 or variant 3 (<i>ROR1<sup>V3</sup></i>), was a predominant <i>ROR1</i> transcript of neoplastic or normal cells in the Bioinformatic database, including GTEx and the 33 datasets from TCGA. Unlike the full-length <i>ROR1</i> transcript, Drs. John and Ford deduced that <i>ROR1<sup>V3</sup></i> encoded a cytoplasmic ROR1 protein lacking an apparent signal peptide necessary for transport to the cell surface, which they presumed made it unlikely to function as a surface receptor for Wingless/Integrated (Wnt) factors. Moreover, they speculated that studies evaluating ROR1 via immunohistochemistry using any one of several anti-ROR1 mA"],"journal":["Biomedicines"],"pubmed_title":["Variant Transcript of ROR1 ENST00000545203 Does Not Encode ROR1 Protein."],"pmcid":["PMC11274362"],"funding_grant_id":["1007844"],"pubmed_authors":["Girgis C","Kipps TJ","Xian J","Widhopf GF","Cring MR","Oh CS","Sinha N"],"additional_accession":[]},"is_claimable":false,"name":"Variant Transcript of ROR1 ENST00000545203 Does Not Encode ROR1 Protein.","description":"Drs. John and Ford reported in <i>biomedicines</i> that a variant transcript encoding receptor tyrosine kinase-like orphan receptor 1 (ROR1), namely ENST00000545203 or variant 3 (<i>ROR1<sup>V3</sup></i>), was a predominant <i>ROR1</i> transcript of neoplastic or normal cells in the Bioinformatic database, including GTEx and the 33 datasets from TCGA. Unlike the full-length <i>ROR1</i> transcript, Drs. John and Ford deduced that <i>ROR1<sup>V3</sup></i> encoded a cytoplasmic ROR1 protein lacking an apparent signal peptide necessary for transport to the cell surface, which they presumed made it unlikely to function as a surface receptor for Wingless/Integrated (Wnt) factors. Moreover, they speculated that studies evaluating ROR1 via immunohistochemistry using any one of several anti-ROR1 mA","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jul","modification":"2026-04-08T18:48:45.051Z","creation":"2025-05-29T22:29:20.34Z"},"accession":"S-EPMC11274362","cross_references":{"pubmed":["39062146"],"doi":["10.3390/biomedicines12071573"]}}