{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Budny V"],"funding":["Hartmann Müller Foundation","Dr. Wilhelm Hurka Foundation"],"pagination":["1207"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11274733"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(14)"],"pubmed_abstract":["The apolipoprotein E4 (<i>APOE4</i>) allele represents the major genetic risk factor for Alzheimer's disease (AD). In contrast, <i>APOE2</i> is known to lower the AD risk, while <i>APOE3</i> is defined as risk neutral. APOE plays a prominent role in the bioenergetic homeostasis of the brain, and early-stage metabolic changes have been detected in the brains of AD patients. Although APOE is primarily expressed by astrocytes in the brain, neurons have also been shown as source for APOE. However, the distinct roles of the three APOE isoforms in neuronal energy homeostasis remain poorly understood. In this study, we generated pure human neurons (iN cells) from <i>APOE</i>-isogenic induced pluripotent stem cells (iPSCs), expressing either APOE2, APOE3, APOE4, or carrying an <i>APOE</i> knockout"],"journal":["Cells"],"pubmed_title":["APOE4 Increases Energy Metabolism in APOE-Isogenic iPSC-Derived Neurons."],"pmcid":["PMC11274733"],"funding_grant_id":["2711","n.a."],"pubmed_authors":["Tardy M","Meier D","Zurcher K","Peter SL","Budny V","Knopfli Y","Muller T","Cortijo C","Bodenmann C","Tackenberg C"],"additional_accession":[]},"is_claimable":false,"name":"APOE4 Increases Energy Metabolism in APOE-Isogenic iPSC-Derived Neurons.","description":"The apolipoprotein E4 (<i>APOE4</i>) allele represents the major genetic risk factor for Alzheimer's disease (AD). In contrast, <i>APOE2</i> is known to lower the AD risk, while <i>APOE3</i> is defined as risk neutral. APOE plays a prominent role in the bioenergetic homeostasis of the brain, and early-stage metabolic changes have been detected in the brains of AD patients. Although APOE is primarily expressed by astrocytes in the brain, neurons have also been shown as source for APOE. However, the distinct roles of the three APOE isoforms in neuronal energy homeostasis remain poorly understood. In this study, we generated pure human neurons (iN cells) from <i>APOE</i>-isogenic induced pluripotent stem cells (iPSCs), expressing either APOE2, APOE3, APOE4, or carrying an <i>APOE</i> knockout","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jul","modification":"2026-04-21T03:25:27.06Z","creation":"2025-04-19T13:12:07.444Z"},"accession":"S-EPMC11274733","cross_references":{"pubmed":["39056789"],"doi":["10.3390/cells13141207"]}}