{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Li Y"],"funding":["Natural Science Foundation of Guangdong Province","Science and Technology Planning Project of Shenzhen Municipality"],"pagination":["873"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11274912"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(7)"],"pubmed_abstract":["Guanylate binding protein 5 (GBP5) is an emerging immune component that has been increasingly recognized for its involvement in autoimmune diseases, particularly inflammatory bowel disease (IBD). IBD is a complex disease involving inflammation of the gastrointestinal tract. Here, we explored the functional significance of GBP5 using <i>Gbp5</i> knockout mice and wildtype mice exposed to dextran sulfate sodium (DSS) to generate chronic colitis model. We found that <i>Gbp5</i> deficiency protected mice from DSS-induced chronic colitis. Transcriptome analysis of colon tissues showed reduced immune responses in <i>Gbp5</i> knockout mice compared to those in corresponding wildtype mice. We further observed that after repeated DSS exposure, the gut microbiota was altered, both in wildtype mice a"],"journal":["Biomolecules"],"pubmed_title":["Diminished Immune Response and Elevated Abundance in Gut Microbe Dubosiella in Mouse Models of Chronic Colitis with GBP5 Deficiency."],"pmcid":["PMC11274912"],"funding_grant_id":["2021A1515012478","JCYJ20190807160411245"],"pubmed_authors":["Hou L","Liu Y","Li Y","Li S","Wang W","Wang J"],"additional_accession":[]},"is_claimable":false,"name":"Diminished Immune Response and Elevated Abundance in Gut Microbe Dubosiella in Mouse Models of Chronic Colitis with GBP5 Deficiency.","description":"Guanylate binding protein 5 (GBP5) is an emerging immune component that has been increasingly recognized for its involvement in autoimmune diseases, particularly inflammatory bowel disease (IBD). IBD is a complex disease involving inflammation of the gastrointestinal tract. Here, we explored the functional significance of GBP5 using <i>Gbp5</i> knockout mice and wildtype mice exposed to dextran sulfate sodium (DSS) to generate chronic colitis model. We found that <i>Gbp5</i> deficiency protected mice from DSS-induced chronic colitis. Transcriptome analysis of colon tissues showed reduced immune responses in <i>Gbp5</i> knockout mice compared to those in corresponding wildtype mice. We further observed that after repeated DSS exposure, the gut microbiota was altered, both in wildtype mice a","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jul","modification":"2025-08-27T03:11:00.875Z","creation":"2025-08-27T03:11:00.875Z"},"accession":"S-EPMC11274912","cross_references":{"pubmed":["39062588"],"doi":["10.3390/biom14070873"]}}