biostudies-literatureUnknownKatrinli SBLRD VANCATS NIH HHSNICHD NIH HHSNIDA NIH HHSNIA NIH HHSNIMH NIH HHSNIMHD NIH HHSNIOSH CDC HHSCSRD VA<h4>Background</h4>The occurrence of post-traumatic stress disorder (PTSD) following a traumatic event is associated with biological differences that can represent the susceptibility to PTSD, the impact of trauma, or the sequelae of PTSD itself. These effects include differences in DNA methylation (DNAm), an important form of epigenetic gene regulation, at multiple CpG loci across the genome. Moreover, these effects can be shared or specific to both central and peripheral tissues. Here, we aim to identify blood DNAm differences associated with PTSD and characterize the underlying biological mechanisms by examining the extent to which they mirror associations across multiple brain regions.<h4>Methods</h4>As the Psychiatric Genomics Consortium (PGC) PTSD Epigenetics Workgroup, we conducted tmedRxiv : the preprint server for health sciences2024.07.15.24310422https://www.ebi.ac.uk/biostudies/studies/S-EPMC11275670biostudies-literatureEpigenome-wide association studies identify novel DNA methylation sites associated with PTSD: A meta-analysis of 23 military and civilian cohorts.PMC11275670R01 MD011728IK2 CX000525UL1 TR000433U01 MH110925U01 OH012466I01 BX003477R01 MH117291R21 AG061367R21 MH102834R21 MH085436R01 MH117293R01 MH117292I01 CX001276IK6 BX006186R01 MH108826R01 MH105379R15 HD049907R01 MH079806RF1 AG068121I21 BX005872R21 DA050160I01 CX000431I01 BX002577R03 AG051877DP1 DA058737R01 MH093500R15 MH099521R01 MH106595K12 HD085850U01 MH115485Wani AHGalea SLuft BJMehta DMarx CEKimbrel NAMilberg WNievergelt CMAvetyan DWildman DEChen CYNunez-Rios DLFatumo SLinnstaedt SDMutesa LLogue MWGeuze EVinkers CHOrcutt HKRauch SAMDaskalakis NPFortier CGarrett MEVermetten EMaihofer AXQin XJBeckham JCBrick LADalvie SMutabaruka JUwineza AHayes JPWare EBLori ARutten BPFHemmings SMUrsano RJAshley-Koch AEChampagne FARatanatharathorn ALuykx JJStein MBVerfaellie MHMichael A HauserNemeroff CBBaker DGGrant GZhao YZhao XBromet ESmith AKRessler KJToikumo SAiello AEBoks MPKessler RCMcLean SAKoenen KCRisbrough VBWolf EJKoen NKuan PFPGC-PTSD Epigenetics Workgroup, PsychENCODE PTSD Brainomics Project, Traumatic Stress Brain Research GroupMiller MWHuber BRMufford MSYoung RMKleinman JEKing APKatrinli SSeedat SJajoo ALiberzon IMusanabaganwa CDennis MFUddin MJansen SStein DJMontalvo-Ortiz JZannas ASNugent NRRutembesa Evan den Heuvel LLfalseEpigenome-wide association studies identify novel DNA methylation sites associated with PTSD: A meta-analysis of 23 military and civilian cohorts.<h4>Background</h4>The occurrence of post-traumatic stress disorder (PTSD) following a traumatic event is associated with biological differences that can represent the susceptibility to PTSD, the impact of trauma, or the sequelae of PTSD itself. These effects include differences in DNA methylation (DNAm), an important form of epigenetic gene regulation, at multiple CpG loci across the genome. Moreover, these effects can be shared or specific to both central and peripheral tissues. Here, we aim to identify blood DNAm differences associated with PTSD and characterize the underlying biological mechanisms by examining the extent to which they mirror associations across multiple brain regions.<h4>Methods</h4>As the Psychiatric Genomics Consortium (PGC) PTSD Epigenetics Workgroup, we conducted t2024-01-01T00:00:00Z2024 Jul2025-04-04T20:27:17.852Z2025-04-04T20:27:17.852ZS-EPMC112756703907201210.1101/2024.07.15.24310422