biostudies-literatureUnknownChoi JNIBIB NIH HHSNCATS NIH HHSNCI NIH HHSAutophagy is known to suppress tumor initiation by removing genotoxic stresses in normal cells. Conversely, autophagy is also known to support tumor progression by alleviating metabolic stresses in neoplastic cells. Centered on this pro-tumor role of autophagy, there have been many clinical trials to treat cancers through systemic blocking of autophagy. Such systemic inhibition affects both tumor cells and non-tumor cells, and the consequence of blocked autophagy in non-tumor cells in the context of tumor microenvironment is relatively understudied. Here, we examined the effect of autophagy-deficient myeloid cells on the progression of autophagy-competent tumors. We found that blocking autophagy only in myeloid cells modulated tumor progression markedly but such effects were context dependbioRxiv : the preprint server for biology2024.07.12.603292https://www.ebi.ac.uk/biostudies/studies/S-EPMC11275940biostudies-literatureContext-dependent roles for autophagy in myeloid cells in tumor progression.PMC11275940DP2 CA225208R01 CA232419UL1 TR000430K99 EB022636R01 CA199663R00 EB022636P30 CA014599Macleod KFPark GBecker LHwang SLee SSDominici EChoi JKron SJfalseContext-dependent roles for autophagy in myeloid cells in tumor progression.Autophagy is known to suppress tumor initiation by removing genotoxic stresses in normal cells. Conversely, autophagy is also known to support tumor progression by alleviating metabolic stresses in neoplastic cells. Centered on this pro-tumor role of autophagy, there have been many clinical trials to treat cancers through systemic blocking of autophagy. Such systemic inhibition affects both tumor cells and non-tumor cells, and the consequence of blocked autophagy in non-tumor cells in the context of tumor microenvironment is relatively understudied. Here, we examined the effect of autophagy-deficient myeloid cells on the progression of autophagy-competent tumors. We found that blocking autophagy only in myeloid cells modulated tumor progression markedly but such effects were context depend2024-01-01T00:00:00Z2024 Jul2026-04-14T03:11:46.99Z2025-04-06T14:23:11.817ZS-EPMC112759403907130610.1101/2024.07.12.603292