{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Loaiza-Cano V"],"funding":["Minciencias","CONADI","MINCIENCIAS"],"pagination":["7972"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11277544"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["25(14)"],"pubmed_abstract":["Although the disease caused by chikungunya virus (CHIKV) is of great interest to public health organizations around the world, there are still no authorized antivirals for its treatment. Previously, dihalogenated anti-CHIKV compounds derived from L-tyrosine (dH-Y) were identified as being effective against in vitro infection by this virus, so the objective of this study was to determine the mechanisms of its antiviral action. Six dH-Y compounds (C1 to C6) dihalogenated with bromine or chlorine and modified in their amino groups were evaluated by different in vitro antiviral strategies and in silico tools. When the cells were exposed before infection, all compounds decreased the expression of viral proteins; only C4, C5 and C6 inhibited the genome; and C1, C2 and C3 inhibited infectious vir"],"journal":["International journal of molecular sciences"],"pubmed_title":["The Mechanism of Action of L-Tyrosine Derivatives against Chikungunya Virus Infection In Vitro Depends on Structural Changes."],"pmcid":["PMC11277544"],"funding_grant_id":["This research was funded by Minciencias (Ministerio de Ciencia Tecnología e Innovación Depar-tamento Administrativo de Ciencia, Tecnología e Investigación). Project No. 141577757439; and CONADI (Universidad Cooperativa de Colombia. Project No. INV2407. V.","141577757439","INV2407"],"pubmed_authors":["Martinez-Gutierrez M","Galeano E","Loaiza-Cano V","Pastrana-Restrepo M","Hernandez-Mira E","Pardo-Rodriguez D"],"additional_accession":[]},"is_claimable":false,"name":"The Mechanism of Action of L-Tyrosine Derivatives against Chikungunya Virus Infection In Vitro Depends on Structural Changes.","description":"Although the disease caused by chikungunya virus (CHIKV) is of great interest to public health organizations around the world, there are still no authorized antivirals for its treatment. Previously, dihalogenated anti-CHIKV compounds derived from L-tyrosine (dH-Y) were identified as being effective against in vitro infection by this virus, so the objective of this study was to determine the mechanisms of its antiviral action. Six dH-Y compounds (C1 to C6) dihalogenated with bromine or chlorine and modified in their amino groups were evaluated by different in vitro antiviral strategies and in silico tools. When the cells were exposed before infection, all compounds decreased the expression of viral proteins; only C4, C5 and C6 inhibited the genome; and C1, C2 and C3 inhibited infectious vir","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jul","modification":"2026-04-21T03:17:26.422Z","creation":"2025-04-19T13:10:34.618Z"},"accession":"S-EPMC11277544","cross_references":{"pubmed":["39063216"],"doi":["10.3390/ijms25147972"]}}