biostudies-literatureOuyang ANSFFootball Players Health Study (FPHS) at Harvard UniversityMcCance Center for Brain HealthGlenn Foundation for Medical ResearchAmerican Academy of Sleep MedicineAmerican Federation for Aging ResearchCure Alzheimer’s FundMcCance CenterNIHDepartment of Defense855https://www.ebi.ac.uk/biostudies/studies/S-EPMC11278044biostudies-literatureUnknown14(7)<h4>Backgrounds</h4>Sleep disturbances are prevalent among elderly individuals. While polysomnography (PSG) serves as the gold standard for sleep monitoring, its extensive setup and data analysis procedures impose significant costs and time constraints, thereby restricting the long-term application within the general public. Our laboratory introduced an innovative biomarker, utilizing artificial intelligence algorithms applied to PSG data to estimate brain age (BA), a metric validated in cohorts with cognitive impairments. Nevertheless, the potential of exercise, which has been a recognized means of enhancing sleep quality in middle-aged and older adults to reduce BA, remains undetermined.<h4>Methods</h4>We conducted an exploratory study to evaluate whether 12 weeks of moderate-intensity eLife (Basel, Switzerland)Effects of Aerobic Exercise on Brain Age and Health in Middle-Aged and Older Adults: A Single-Arm Pilot Clinical Trial.PMC11278044R01NS102190R01NS107291R01AG062989RF1AG0643122014431Brain HealthR01NS102574R01AG073410Tesh RAAdra NJing JWrann CDChemali ZLei DPaixao LFan PBevers MBRosand JOuyang ASalinas JFricchione GGanglberger WTanzi REWestover MBBriggs LThomas RJZhang CSun HfalseEffects of Aerobic Exercise on Brain Age and Health in Middle-Aged and Older Adults: A Single-Arm Pilot Clinical Trial.<h4>Backgrounds</h4>Sleep disturbances are prevalent among elderly individuals. While polysomnography (PSG) serves as the gold standard for sleep monitoring, its extensive setup and data analysis procedures impose significant costs and time constraints, thereby restricting the long-term application within the general public. Our laboratory introduced an innovative biomarker, utilizing artificial intelligence algorithms applied to PSG data to estimate brain age (BA), a metric validated in cohorts with cognitive impairments. Nevertheless, the potential of exercise, which has been a recognized means of enhancing sleep quality in middle-aged and older adults to reduce BA, remains undetermined.<h4>Methods</h4>We conducted an exploratory study to evaluate whether 12 weeks of moderate-intensity e2024-01-01T00:00:00Z2024 Jul2026-05-22T03:17:52.935Z2025-04-19T13:14:47.094ZS-EPMC112780443906360910.3390/life14070855