biostudies-literatureUnknown13(14)von Stein P<b>Background/Objectives:</b> Previous trials reported comparable results with PASCAL and earlier MitraClip generations. Limited comparative data exist for more contemporary MitraClip generations, particularly the large MitraClip XT(R/W). We aimed to evaluate acute and 30-day outcomes in patients undergoing mitral valve transcatheter edge-to-edge repair (M-TEER) with one of the large devices, either PASCAL P10 or MitraClip XT(R/W) (3rd/4th generation). <b>Methods:</b> A total of 309 PASCAL-treated patients were matched by propensity score to 253 MitraClip-treated patients, resulting in 200 adequately balanced pairs. Procedural, clinical, and echocardiographic outcomes were collected for up to 30 days, including subgroup analysis for mitral regurgitation (MR) etiologies. <b>Results</b>: PASJournal of clinical medicine4187https://www.ebi.ac.uk/biostudies/studies/S-EPMC11278441biostudies-literatureEarly Outcomes of Two Large Mitral Valve Transcatheter Edge-to-Edge Repair Devices-A Propensity Score Matched Multicenter Comparison.PMC11278441Mauri VLuedike PRudolph FThiele HPfister RBoeder NMollmann HNovotny JRassaf TKelm MPolzin ATanaka TKavsur RMues CWienemann HWeber MWeckbach Lvon Bardeleben RSOzturk CHaurand JMBaldus Svon Stein PGrothusen CRuf TNef HGuthoff Hvon Stein JSugiura AGercek MHausleiter JKister TLurz PRudolph VMahabadi AAHorn PfalseEarly Outcomes of Two Large Mitral Valve Transcatheter Edge-to-Edge Repair Devices-A Propensity Score Matched Multicenter Comparison.<b>Background/Objectives:</b> Previous trials reported comparable results with PASCAL and earlier MitraClip generations. Limited comparative data exist for more contemporary MitraClip generations, particularly the large MitraClip XT(R/W). We aimed to evaluate acute and 30-day outcomes in patients undergoing mitral valve transcatheter edge-to-edge repair (M-TEER) with one of the large devices, either PASCAL P10 or MitraClip XT(R/W) (3rd/4th generation). <b>Methods:</b> A total of 309 PASCAL-treated patients were matched by propensity score to 253 MitraClip-treated patients, resulting in 200 adequately balanced pairs. Procedural, clinical, and echocardiographic outcomes were collected for up to 30 days, including subgroup analysis for mitral regurgitation (MR) etiologies. <b>Results</b>: PAS2024-01-01T00:00:00Z2024 Jul2026-04-15T03:21:35.582Z2025-08-31T03:04:56.622ZS-EPMC112784413906422710.3390/jcm13144187