{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10(13)"],"submitter":["Hua M"],"pubmed_abstract":["Ovarian cancer (OC) is a common and lethal gynaecological malignancy. RNA-binding proteins (RBPs) play a crucial role in governing RNA metabolism and have been implicated in the development and progression of diverse cancer types. Slight alterations in RBPs' expression or activity can induce substantial modifications in the regulatory network. THUMPD2, as member of the RBP family, was found to have differential expression in ovarian cancer, with the mechanism has not been studied yet. In this study, THUMPD2 protein was found to be weakly expressed in the early (I + II) stages of OC (P = 0.013), with a low expression rate of 78.6 %, and highly expressed in late (III + IV) stages (P = 0.009), with a high expression rate of 84.8 %. The shRNA-mediated knockdown of THUMPD2 in OVCAR3 and SKOV3 c"],"journal":["Heliyon"],"pagination":["e33201"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11279259"],"repository":["biostudies-literature"],"pubmed_title":["RNA-binding protein THUMPD2 inhibits proliferation and promotes metastasis in epithelial ovarian cancer."],"pmcid":["PMC11279259"],"pubmed_authors":["Lv W","Zhang Y","Chen Y","Hua M","Jia M","Xu Y"],"additional_accession":[]},"is_claimable":false,"name":"RNA-binding protein THUMPD2 inhibits proliferation and promotes metastasis in epithelial ovarian cancer.","description":"Ovarian cancer (OC) is a common and lethal gynaecological malignancy. RNA-binding proteins (RBPs) play a crucial role in governing RNA metabolism and have been implicated in the development and progression of diverse cancer types. Slight alterations in RBPs' expression or activity can induce substantial modifications in the regulatory network. THUMPD2, as member of the RBP family, was found to have differential expression in ovarian cancer, with the mechanism has not been studied yet. In this study, THUMPD2 protein was found to be weakly expressed in the early (I + II) stages of OC (P = 0.013), with a low expression rate of 78.6 %, and highly expressed in late (III + IV) stages (P = 0.009), with a high expression rate of 84.8 %. The shRNA-mediated knockdown of THUMPD2 in OVCAR3 and SKOV3 c","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jul","modification":"2026-05-28T03:16:23.803Z","creation":"2025-04-19T13:11:03.103Z"},"accession":"S-EPMC11279259","cross_references":{"pubmed":["39071668"],"doi":["10.1016/j.heliyon.2024.e33201"]}}