{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12(7)"],"submitter":["Zeng X"],"pubmed_abstract":["Subgroup J avian leukosis virus (<b>ALV-J</b>) is a major pathogen in poultry, causing substantial economic losses to the poultry industry worldwide. Exosomal small RNAs derived from virus-infected cells or biological fluids can serve as viral transmission vectors. However, the role and mechanism of exosomal miRNA in ALV-J infection are unclear. In this study, we demonstrated that exosomal microRNA-7-25207 (<b>miR-7-25207</b>) could increase the titers of ALV-J. Exosomes isolated from ALV-J-infected DF-1 cells (<b>Exo-ALV-J</b>) contained partial viral proteins from ALV-J and could transmit the infection to uninfected DF-1 cells, leading to productive infection. Additionally, the RNA expression profile of exosomes was altered following ALV-J infection. miRNA analysis revealed that the expr"],"journal":["Microorganisms"],"pagination":["1495"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11279298"],"repository":["biostudies-literature"],"pubmed_title":["Exosomal miR-7-25207 Increases Subgroup J Avian Leukosis Virus Titers by Targeting the Akt-CyclinQ1 and PRC1-YAF2 Dual Pathways."],"pmcid":["PMC11279298"],"pubmed_authors":["Dong X","Chen L","Zeng X","Liu T","Kong J","Xie Q","Dai Z","Li Y","Liao L","Feng K","Tang S","Wong YH","Chen S"],"additional_accession":[]},"is_claimable":false,"name":"Exosomal miR-7-25207 Increases Subgroup J Avian Leukosis Virus Titers by Targeting the Akt-CyclinQ1 and PRC1-YAF2 Dual Pathways.","description":"Subgroup J avian leukosis virus (<b>ALV-J</b>) is a major pathogen in poultry, causing substantial economic losses to the poultry industry worldwide. Exosomal small RNAs derived from virus-infected cells or biological fluids can serve as viral transmission vectors. However, the role and mechanism of exosomal miRNA in ALV-J infection are unclear. In this study, we demonstrated that exosomal microRNA-7-25207 (<b>miR-7-25207</b>) could increase the titers of ALV-J. Exosomes isolated from ALV-J-infected DF-1 cells (<b>Exo-ALV-J</b>) contained partial viral proteins from ALV-J and could transmit the infection to uninfected DF-1 cells, leading to productive infection. Additionally, the RNA expression profile of exosomes was altered following ALV-J infection. miRNA analysis revealed that the expr","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jul","modification":"2026-06-30T03:10:48.147Z","creation":"2025-04-19T13:12:56.345Z"},"accession":"S-EPMC11279298","cross_references":{"pubmed":["39065263"],"doi":["10.3390/microorganisms12071495"]}}