{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Uchida-Fujii E"],"funding":["Ministry of Agriculture, Forestry and Fisheries"],"pagination":["597"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11279536"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(7)"],"pubmed_abstract":["Equus caballus papillomavirus 2 (EcPV2) is known to cause genital neoplasms in horses. However, reports on EcPV2 in Japan and Asia are limited. Herein, we present the histopathological and virological findings of the first reported case of an EcPV2-associated penile mass in Japan. The patient was a 22-year-old stallion with a history of breeding in Japan and abroad. Histopathological examination contained RNA in situ hybridization targeting the E6/E7 region and an immunohistochemical approach, and whole-genome sequencing was conducted within the viral examination. Proliferating epidermal cells were observed, and EcPV2 E6/E7 mRNA was detected within the epidermis, which was interpreted as viral papilloma. The detected EcPV2 virus was genetically close to foreign strains and different from t"],"journal":["Pathogens (Basel, Switzerland)"],"pubmed_title":["Histopathological and Virological Findings of a Penile Papilloma in a Japanese Stallion with Equus Caballus Papillomavirus 2 (EcPV2)."],"pmcid":["PMC11279536"],"funding_grant_id":["JPJ009417"],"pubmed_authors":["Uchida-Fujii E","Kato Y","Numasawa Y","Haga T","Yusa S","Ueno T"],"additional_accession":[]},"is_claimable":false,"name":"Histopathological and Virological Findings of a Penile Papilloma in a Japanese Stallion with Equus Caballus Papillomavirus 2 (EcPV2).","description":"Equus caballus papillomavirus 2 (EcPV2) is known to cause genital neoplasms in horses. However, reports on EcPV2 in Japan and Asia are limited. Herein, we present the histopathological and virological findings of the first reported case of an EcPV2-associated penile mass in Japan. The patient was a 22-year-old stallion with a history of breeding in Japan and abroad. Histopathological examination contained RNA in situ hybridization targeting the E6/E7 region and an immunohistochemical approach, and whole-genome sequencing was conducted within the viral examination. Proliferating epidermal cells were observed, and EcPV2 E6/E7 mRNA was detected within the epidermis, which was interpreted as viral papilloma. The detected EcPV2 virus was genetically close to foreign strains and different from t","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jul","modification":"2026-04-08T19:21:26.105Z","creation":"2025-04-19T13:11:10.139Z"},"accession":"S-EPMC11279536","cross_references":{"pubmed":["39057823"],"doi":["10.3390/pathogens13070597"]}}