{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Marquez-Garban DC"],"funding":["California Breast Cancer Research Program","UCLA Jonsson Comprehensive Cancer Center","Hickey Family Foundation","NCI NIH HHS"],"pagination":["2369"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11279598"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(14)"],"pubmed_abstract":["Manuka honey (MH) exhibits potential antitumor activity in preclinical models of a number of human cancers. Treatment in vitro with MH at concentrations ranging from 0.3 to 5.0% (<i>w</i>/<i>v</i>) led to significant dose-dependent inhibition of proliferation of human breast cancer MCF-7 cells, but anti-proliferative effects of MH were less pronounced in MDA-MB-231 breast cancer cells. Effects of MH were also tested on non-malignant human mammary epithelial cells (HMECs) at 2.5% <i>w</i>/<i>v</i>, and it was found that MH reduced the proliferation of MCF-7 cells but not that of HMECs. Notably, the antitumor activity of MH was in the range of that exerted by treatment of MCF-7 cells with the antiestrogen tamoxifen. Further, MH treatment stimulated apoptosis of MCF-7 cells in vitro, with mos"],"journal":["Nutrients"],"pubmed_title":["Manuka Honey Inhibits Human Breast Cancer Progression in Preclinical Models."],"pmcid":["PMC11279598"],"funding_grant_id":["U54 CA143930","Breast Cancer Research Award","N.A.","B27IB3869"],"pubmed_authors":["McCloskey SA","Wadehra M","Yanes CD","Hardy M","Llarena G","Elashoff D","Hamilton N","Pietras RJ","Marquez-Garban DC"],"additional_accession":[]},"is_claimable":false,"name":"Manuka Honey Inhibits Human Breast Cancer Progression in Preclinical Models.","description":"Manuka honey (MH) exhibits potential antitumor activity in preclinical models of a number of human cancers. Treatment in vitro with MH at concentrations ranging from 0.3 to 5.0% (<i>w</i>/<i>v</i>) led to significant dose-dependent inhibition of proliferation of human breast cancer MCF-7 cells, but anti-proliferative effects of MH were less pronounced in MDA-MB-231 breast cancer cells. Effects of MH were also tested on non-malignant human mammary epithelial cells (HMECs) at 2.5% <i>w</i>/<i>v</i>, and it was found that MH reduced the proliferation of MCF-7 cells but not that of HMECs. Notably, the antitumor activity of MH was in the range of that exerted by treatment of MCF-7 cells with the antiestrogen tamoxifen. Further, MH treatment stimulated apoptosis of MCF-7 cells in vitro, with mos","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jul","modification":"2025-08-27T03:10:55.512Z","creation":"2025-08-27T03:10:55.512Z"},"accession":"S-EPMC11279598","cross_references":{"pubmed":["39064812"],"doi":["10.3390/nu16142369"]}}