biostudies-literatureZheleznyak ANIBIB NIH HHSNCI NIH HHSNIHNIH HHS738-752https://www.ebi.ac.uk/biostudies/studies/S-EPMC11282151biostudies-literatureUnknown26(4)<h4>Purpose</h4>Multiple myeloma (MM) affects over 35,000 patients each year in the US. There remains a need for versatile Positron Emission Tomography (PET) tracers for the detection, accurate staging, and monitoring of treatment response of MM that have optimal specificity and translational attributes. CD38 is uniformly overexpressed in MM and thus represents an ideal target to develop CD38-targeted small molecule PET radiopharmaceuticals to address these challenges.<h4>Procedures</h4>Using phage display peptide libraries and pioneering algorithms, we identified novel CD38 specific peptides. Imaging bioconjugates were synthesized using solid phase peptide chemistry, and systematically analyzed in vitro and in vivo in relevant MM systems.<h4>Results</h4>The CD38-targeted bioconjugates werMolecular imaging and biologyDevelopment of New CD38 Targeted Peptides for Cancer Imaging.PMC11282151T32 EB014855R01 CA248493P30 CA091842R42 CA257797S10 OD027042S10 OD025264R01 CA176221R01 CA260855P50 CA094056Duncan KPrior JGhai AVanover AZheleznyak AAchilefu SLees SXu BManion BLiang KTang RShokeen MKelly KfalseDevelopment of New CD38 Targeted Peptides for Cancer Imaging.<h4>Purpose</h4>Multiple myeloma (MM) affects over 35,000 patients each year in the US. There remains a need for versatile Positron Emission Tomography (PET) tracers for the detection, accurate staging, and monitoring of treatment response of MM that have optimal specificity and translational attributes. CD38 is uniformly overexpressed in MM and thus represents an ideal target to develop CD38-targeted small molecule PET radiopharmaceuticals to address these challenges.<h4>Procedures</h4>Using phage display peptide libraries and pioneering algorithms, we identified novel CD38 specific peptides. Imaging bioconjugates were synthesized using solid phase peptide chemistry, and systematically analyzed in vitro and in vivo in relevant MM systems.<h4>Results</h4>The CD38-targeted bioconjugates wer2024-01-01T00:00:00Z2024 Aug2026-05-02T03:36:33.963Z2026-04-07T17:35:59.206ZS-EPMC112821513848065010.1007/s11307-024-01901-5