{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Li S"],"funding":["Yongping Xu","Xiaoyu Li","Jiajun Yin","Jibin Li"],"pagination":["428"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11283397"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["108(1)"],"pubmed_abstract":["Acinetobacter baumannii, which is resistant to multiple drugs, is an opportunistic pathogen responsible for severe nosocomial infections. With no antibiotics available, phages have obtained clinical attention. However, since immunocompromised patients are often susceptible to infection, the appropriate timing of administration is particularly important. During this research, we obtained a lytic phage vB_AbaM_P1 that specifically targets A. baumannii. We then assessed its potential as a prophylactic treatment for lung infections caused by clinical strains. The virus experiences a period of inactivity lasting 30 min and produces approximately 788 particles during an outbreak. Transmission electron microscopy shows that vB_AbaM_P1 was similar to the Saclayvirus. Based on the analysis of high-"],"journal":["Applied microbiology and biotechnology"],"pubmed_title":["A novel Saclayvirus Acinetobacter baumannii phage genomic analysis and effectiveness in preventing pneumonia."],"pmcid":["PMC11283397"],"funding_grant_id":["DUT23YG214","No.2022JH1/10900013","No. 243","2021","2021YF16SN012"],"pubmed_authors":["Xu L","Li X","Li J","Xu M","Li S","Wei B","Murtaza B","Cong C","Wang L","Yin J","Xu Y"],"additional_accession":[]},"is_claimable":false,"name":"A novel Saclayvirus Acinetobacter baumannii phage genomic analysis and effectiveness in preventing pneumonia.","description":"Acinetobacter baumannii, which is resistant to multiple drugs, is an opportunistic pathogen responsible for severe nosocomial infections. With no antibiotics available, phages have obtained clinical attention. However, since immunocompromised patients are often susceptible to infection, the appropriate timing of administration is particularly important. During this research, we obtained a lytic phage vB_AbaM_P1 that specifically targets A. baumannii. We then assessed its potential as a prophylactic treatment for lung infections caused by clinical strains. The virus experiences a period of inactivity lasting 30 min and produces approximately 788 particles during an outbreak. Transmission electron microscopy shows that vB_AbaM_P1 was similar to the Saclayvirus. Based on the analysis of high-","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jul","modification":"2026-06-03T03:39:13.942Z","creation":"2026-05-28T03:06:23.231Z"},"accession":"S-EPMC11283397","cross_references":{"pubmed":["39066795"],"doi":["10.1007/s00253-024-13208-0"]}}