{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15"],"submitter":["Le Menn G"],"pubmed_abstract":["<h4>Introduction</h4>Ubiquitin-specific proteases (USPs), a large subset of more than 50 deubiquitinase proteins, have recently emerged as promising targets in cancer. However, their role in immune cell regulation, particularly in T cell activation, differentiation, and effector functions, remains largely unexplored.<h4>Methods</h4>We utilized a USP28 knockout mouse line to study the effect of USP28 on T cell activation and function, and its role in intestinal inflammation using the dextran sulfate sodium (DSS)-induced colitis model and a series of in vitro assays.<h4>Results</h4>Our results show that USP28 exerts protective effects in acute intestinal inflammation. Mechanistically, USP28 knockout mice (USP28-/-) exhibited an increase in total T cells mainly due to an increased CD8+ T cell"],"journal":["Frontiers in immunology"],"pagination":["1401949"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11284026"],"repository":["biostudies-literature"],"pubmed_title":["USP28 protects development of inflammation in mouse intestine by regulating STAT5 phosphorylation and IL22 production in T lymphocytes."],"pmcid":["PMC11284026"],"pubmed_authors":["Le Menn G","Pikkarainen K","Miroszewska D","Chen Z","Mennerich D","Kietzmann T"],"additional_accession":[]},"is_claimable":false,"name":"USP28 protects development of inflammation in mouse intestine by regulating STAT5 phosphorylation and IL22 production in T lymphocytes.","description":"<h4>Introduction</h4>Ubiquitin-specific proteases (USPs), a large subset of more than 50 deubiquitinase proteins, have recently emerged as promising targets in cancer. However, their role in immune cell regulation, particularly in T cell activation, differentiation, and effector functions, remains largely unexplored.<h4>Methods</h4>We utilized a USP28 knockout mouse line to study the effect of USP28 on T cell activation and function, and its role in intestinal inflammation using the dextran sulfate sodium (DSS)-induced colitis model and a series of in vitro assays.<h4>Results</h4>Our results show that USP28 exerts protective effects in acute intestinal inflammation. Mechanistically, USP28 knockout mice (USP28-/-) exhibited an increase in total T cells mainly due to an increased CD8+ T cell","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024","modification":"2026-06-01T09:03:18.87Z","creation":"2026-04-08T10:59:06.011Z"},"accession":"S-EPMC11284026","cross_references":{"pubmed":["39076972"],"doi":["10.3389/fimmu.2024.1401949"]}}