{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Bourgonje AR"],"funding":["European Research Council"],"pagination":["141"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11285207"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(1)"],"pubmed_abstract":["<h4>Background</h4>Elevated systemic antibody responses against gut microbiota flagellins are observed in both Crohn's disease (CD) and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), suggesting potential serological biomarkers for diagnosis. However, flagellin-specific antibody repertoires and functional roles in the diseases remain incompletely understood. Bacterial flagellins can be categorized into three types depending on their interaction with toll-like receptor 5 (TLR5): (1) \"stimulator\" and (2) \"silent\" flagellins, which bind TLR5 through a conserved N-terminal motif, with only stimulators activating TLR5 (involving a C-terminal domain); (3) \"evader\" flagellins of pathogens, which entirely circumvent TLR5 activation via mutations in the N-terminal TLR5 binding motif.<h"],"journal":["Microbiome"],"pubmed_title":["Systemic antibody responses against gut microbiota flagellins implicate shared and divergent immune reactivity in Crohn's disease and chronic fatigue syndrome."],"pmcid":["PMC11285207"],"funding_grant_id":["101075733"],"pubmed_authors":["Innocenti G","Fehringer M","Horstke NV","Bourgonje AR","Vogl T"],"additional_accession":[]},"is_claimable":false,"name":"Systemic antibody responses against gut microbiota flagellins implicate shared and divergent immune reactivity in Crohn's disease and chronic fatigue syndrome.","description":"<h4>Background</h4>Elevated systemic antibody responses against gut microbiota flagellins are observed in both Crohn's disease (CD) and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), suggesting potential serological biomarkers for diagnosis. However, flagellin-specific antibody repertoires and functional roles in the diseases remain incompletely understood. Bacterial flagellins can be categorized into three types depending on their interaction with toll-like receptor 5 (TLR5): (1) \"stimulator\" and (2) \"silent\" flagellins, which bind TLR5 through a conserved N-terminal motif, with only stimulators activating TLR5 (involving a C-terminal domain); (3) \"evader\" flagellins of pathogens, which entirely circumvent TLR5 activation via mutations in the N-terminal TLR5 binding motif.<h","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jul","modification":"2026-06-02T18:39:39.248Z","creation":"2025-08-23T03:05:15.929Z"},"accession":"S-EPMC11285207","cross_references":{"pubmed":["39075559"],"doi":["10.1186/s40168-024-01858-1"]}}