{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Chooi WH"],"funding":["National Research Foundation Singapore"],"pagination":["2382235"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11285248"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(1)"],"pubmed_abstract":["Enterovirus A71 (EV-A71) causes Hand, Foot, and Mouth Disease and has been clinically associated with neurological complications. However, there is a lack of relevant models to elucidate the neuropathology of EV-A71 and its mechanism, as the current models mainly utilize animal models or immortalized cell lines. In this study, we established a human motor neuron model for EV-A71 infection. Single cell transcriptomics of a mixed neuronal population reveal higher viral RNA load in motor neurons, suggesting higher infectivity and replication of EV-A71 in motor neurons. The elevated RNA load in motor neurons correlates with the downregulation of ferritin-encoding genes. Subsequent analysis confirms that neurons infected with EV-A71 undergo ferroptosis, as evidenced by increased levels of labil"],"journal":["Emerging microbes & infections"],"pubmed_title":["Enterovirus-A71 preferentially infects and replicates in human motor neurons, inducing neurodegeneration by ferroptosis."],"pmcid":["PMC11285248"],"funding_grant_id":["NRF-CRP21-2018-0004"],"pubmed_authors":["Chooi WH","Chu JJH","Winanto","Gautam P","Alonso S","Loh YH","Lee CY","Ng SY","Zeng Y","Lim ZQ"],"additional_accession":[]},"is_claimable":false,"name":"Enterovirus-A71 preferentially infects and replicates in human motor neurons, inducing neurodegeneration by ferroptosis.","description":"Enterovirus A71 (EV-A71) causes Hand, Foot, and Mouth Disease and has been clinically associated with neurological complications. However, there is a lack of relevant models to elucidate the neuropathology of EV-A71 and its mechanism, as the current models mainly utilize animal models or immortalized cell lines. In this study, we established a human motor neuron model for EV-A71 infection. Single cell transcriptomics of a mixed neuronal population reveal higher viral RNA load in motor neurons, suggesting higher infectivity and replication of EV-A71 in motor neurons. The elevated RNA load in motor neurons correlates with the downregulation of ferritin-encoding genes. Subsequent analysis confirms that neurons infected with EV-A71 undergo ferroptosis, as evidenced by increased levels of labil","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Dec","modification":"2026-06-02T18:39:37.024Z","creation":"2025-08-23T03:05:15.464Z"},"accession":"S-EPMC11285248","cross_references":{"pubmed":["39017655"],"doi":["10.1080/22221751.2024.2382235"]}}