biostudies-literatureUnknown45(2)Lu S<h4>Background and purpose</h4>Collateral circulation plays an important role in steno-occlusive internal carotid artery disease (ICAD) to reduce the risk of stroke. We aimed to investigate the utility of planning-free random vessel-encoded arterial spin-labeling (rVE-ASL) in assessing collateral flows in patients with ICAD.<h4>Materials and methods</h4>Forty patients with ICAD were prospectively recruited. The presence and extent of collateral flow were assessed and compared between rVE-ASL and DSA by using Contingency (C) and Cramer V (V) coefficients. The differences in flow territory alterations stratified by stenosis ratio and symptoms, respectively, were compared between symptomatic (<i>n</i> = 19) and asymptomatic (<i>n</i> = 21) patients by using the Fisher exact test.<h4>Results</h4>Good agreement was observed between rVE-ASL and DSA in assessing collateral flow (C = 0.762, V = 0.833, both <i>P </i>< .001). Patients with ICA stenosis of ≥90% were more likely to have flow alterations (<i>P </i>< .001). Symptomatic patients showed a higher prevalence of flow alterations in the territory of the MCA on the same side of ICAD (63.2%), compared with asymptomatic patients (23.8%, <i>P </i>= .012), while the flow alterations in the territory of anterior cerebral artery did not differ (<i>P </i>= .442). The collateral flow to MCA territory was developed primarily from the contralateral internal carotid artery (70.6%) and vertebrobasilar artery to a lesser extent (47.1%).<h4>Conclusions</h4>rVE-ASL provides comparable information with DSA on the assessment of collateral flow. The flow alterations in the MCA territory may be attributed to symptomatic ICAD.AJNR. American journal of neuroradiology155-162https://www.ebi.ac.uk/biostudies/studies/S-EPMC11285992biostudies-literatureAssessment of Collateral Flow in Patients with Carotid Stenosis Using Random Vessel-Encoded Arterial Spin-Labeling: Comparison with Digital Subtraction Angiography.PMC11285992Yan LSu CHe YCao YLu SShi HJia ZfalseAssessment of Collateral Flow in Patients with Carotid Stenosis Using Random Vessel-Encoded Arterial Spin-Labeling: Comparison with Digital Subtraction Angiography.<h4>Background and purpose</h4>Collateral circulation plays an important role in steno-occlusive internal carotid artery disease (ICAD) to reduce the risk of stroke. We aimed to investigate the utility of planning-free random vessel-encoded arterial spin-labeling (rVE-ASL) in assessing collateral flows in patients with ICAD.<h4>Materials and methods</h4>Forty patients with ICAD were prospectively recruited. The presence and extent of collateral flow were assessed and compared between rVE-ASL and DSA by using Contingency (C) and Cramer V (V) coefficients. The differences in flow territory alterations stratified by stenosis ratio and symptoms, respectively, were compared between symptomatic (<i>n</i> = 19) and asymptomatic (<i>n</i> = 21) patients by using the Fisher exact test.<h4>Results</h4>Good agreement was observed between rVE-ASL and DSA in assessing collateral flow (C = 0.762, V = 0.833, both <i>P </i>< .001). Patients with ICA stenosis of ≥90% were more likely to have flow alterations (<i>P </i>< .001). Symptomatic patients showed a higher prevalence of flow alterations in the territory of the MCA on the same side of ICAD (63.2%), compared with asymptomatic patients (23.8%, <i>P </i>= .012), while the flow alterations in the territory of anterior cerebral artery did not differ (<i>P </i>= .442). The collateral flow to MCA territory was developed primarily from the contralateral internal carotid artery (70.6%) and vertebrobasilar artery to a lesser extent (47.1%).<h4>Conclusions</h4>rVE-ASL provides comparable information with DSA on the assessment of collateral flow. The flow alterations in the MCA territory may be attributed to symptomatic ICAD.2024-01-01T00:00:00Z2024 Feb2025-04-21T23:49:57.569Z2025-04-05T19:21:38.952ZS-EPMC112859923823809110.3174/ajnr.a810010.3174/ajnr.A8100