biostudies-literatureSun BNHLBI NIH HHSNational Institute of Health (NIH) grantsRenji Hospital School of Medicine Shanghai Jiaotong UniversityNational Natural Science Foundation of ChinaScience and Technology Commission of Shanghai Municipality Explorer projectShanghai Municipal Population and Family Planning Commission262-270https://www.ebi.ac.uk/biostudies/studies/S-EPMC11286112biostudies-literatureUnknown45(3)<h4>Background and purpose</h4>Intracranial plaque enhancement (IPE) identified by contrast-enhanced vessel wall MR imaging (VW-MR imaging) is an emerging marker of plaque instability related to stroke risk, but there was no standardized timing for postcontrast acquisition. We aim to explore the optimal postcontrast timing by using multiphase contrast-enhanced VW-MR imaging and to test its performance in differentiating culprit and nonculprit lesions.<h4>Materials and methods</h4>Patients with acute ischemic stroke due to intracranial plaque were prospectively recruited to undergo VW-MR imaging with 1 precontrast phase and 4 consecutive postcontrast phases (9 minutes and 13 seconds for each phase). The signal intensity (SI) values of the CSF and intracranial plaque were measured on 1 precoAJNR. American journal of neuroradiologyDelayed Enhancement of Intracranial Atherosclerotic Plaque Can Better Differentiate Culprit Lesions: A Multiphase Contrast-Enhanced Vessel Wall MRI Study.PMC112861122019NYBSZX01R01HL162743 and R00HL13688322TS140060082271942; 81801650; 823007071020204Y0089;GWVI-11.2-YQ50R01 HL162743R00 HL136883Tian JLi XZhang JSun BZhou YXu JWang LMossa-Basha MZhao HZhu CfalseDelayed Enhancement of Intracranial Atherosclerotic Plaque Can Better Differentiate Culprit Lesions: A Multiphase Contrast-Enhanced Vessel Wall MRI Study.<h4>Background and purpose</h4>Intracranial plaque enhancement (IPE) identified by contrast-enhanced vessel wall MR imaging (VW-MR imaging) is an emerging marker of plaque instability related to stroke risk, but there was no standardized timing for postcontrast acquisition. We aim to explore the optimal postcontrast timing by using multiphase contrast-enhanced VW-MR imaging and to test its performance in differentiating culprit and nonculprit lesions.<h4>Materials and methods</h4>Patients with acute ischemic stroke due to intracranial plaque were prospectively recruited to undergo VW-MR imaging with 1 precontrast phase and 4 consecutive postcontrast phases (9 minutes and 13 seconds for each phase). The signal intensity (SI) values of the CSF and intracranial plaque were measured on 1 preco2024-01-01T00:00:00Z2024 Mar2025-04-03T23:36:32.595Z2025-04-03T23:36:32.595ZS-EPMC112861123838868610.3174/ajnr.A813210.3174/ajnr.a8132