{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15"],"submitter":["Li Y"],"funding":["National Natural Science Foundation of China","National Key Research and Development Program of China"],"pubmed_abstract":["Periodontitis, delineated by the destruction of structures that support teeth, is predominantly propelled by intricate immune responses. Immunomodulatory treatments offer considerable promise for the management of this ailment; however, the modulation of the periodontal immune microenvironment to facilitate tissue regeneration presents a substantial biomedical challenge. Herein, our study investigates the role of Wilms' tumor 1-associating protein (WTAP), a critical m<sup>6</sup>A methyltransferase, in the immunomodulation of periodontitis and assesses its viability as a therapeutic target. We observed heightened expression of WTAP in macrophages extracted from gingival tissues impacted by periodontitis, with a strong association with M1 polarization. Via loss-of-function experiments, we d"],"journal":["Frontiers in immunology"],"pagination":["1423378"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11286459"],"repository":["biostudies-literature"],"pubmed_title":["The role of WTAP in regulating macrophage-mediated osteoimmune responses and tissue regeneration in periodontitis."],"pmcid":["PMC11286459"],"pubmed_authors":["Li Y","Yang Y","Huang Y","Hu Z","Sun S","Chen Y","Hu B","Deng X","Niu Y"],"additional_accession":[]},"is_claimable":false,"name":"The role of WTAP in regulating macrophage-mediated osteoimmune responses and tissue regeneration in periodontitis.","description":"Periodontitis, delineated by the destruction of structures that support teeth, is predominantly propelled by intricate immune responses. Immunomodulatory treatments offer considerable promise for the management of this ailment; however, the modulation of the periodontal immune microenvironment to facilitate tissue regeneration presents a substantial biomedical challenge. Herein, our study investigates the role of Wilms' tumor 1-associating protein (WTAP), a critical m<sup>6</sup>A methyltransferase, in the immunomodulation of periodontitis and assesses its viability as a therapeutic target. We observed heightened expression of WTAP in macrophages extracted from gingival tissues impacted by periodontitis, with a strong association with M1 polarization. Via loss-of-function experiments, we d","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024","modification":"2026-06-03T00:27:04.619Z","creation":"2026-04-22T03:11:50.431Z"},"accession":"S-EPMC11286459","cross_references":{"pubmed":["39081311"],"doi":["10.3389/fimmu.2024.1423378"]}}