biostudies-literatureUnknown15Li YNational Natural Science Foundation of ChinaNational Key Research and Development Program of ChinaPeriodontitis, delineated by the destruction of structures that support teeth, is predominantly propelled by intricate immune responses. Immunomodulatory treatments offer considerable promise for the management of this ailment; however, the modulation of the periodontal immune microenvironment to facilitate tissue regeneration presents a substantial biomedical challenge. Herein, our study investigates the role of Wilms' tumor 1-associating protein (WTAP), a critical m⁶A methyltransferase, in the immunomodulation of periodontitis and assesses its viability as a therapeutic target. We observed heightened expression of WTAP in macrophages extracted from gingival tissues impacted by periodontitis, with a strong association with M1 polarization. Via loss-of-function experiments, we dFrontiers in immunology1423378https://www.ebi.ac.uk/biostudies/studies/S-EPMC11286459biostudies-literatureThe role of WTAP in regulating macrophage-mediated osteoimmune responses and tissue regeneration in periodontitis.PMC11286459Li YYang YHuang YHu ZSun SChen YHu BDeng XNiu YfalseThe role of WTAP in regulating macrophage-mediated osteoimmune responses and tissue regeneration in periodontitis.Periodontitis, delineated by the destruction of structures that support teeth, is predominantly propelled by intricate immune responses. Immunomodulatory treatments offer considerable promise for the management of this ailment; however, the modulation of the periodontal immune microenvironment to facilitate tissue regeneration presents a substantial biomedical challenge. Herein, our study investigates the role of Wilms' tumor 1-associating protein (WTAP), a critical m⁶A methyltransferase, in the immunomodulation of periodontitis and assesses its viability as a therapeutic target. We observed heightened expression of WTAP in macrophages extracted from gingival tissues impacted by periodontitis, with a strong association with M1 polarization. Via loss-of-function experiments, we d2024-01-01T00:00:00Z20242026-06-03T00:27:04.619Z2026-04-22T03:11:50.431ZS-EPMC112864593908131110.3389/fimmu.2024.1423378