{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Amiard S"],"funding":["CNRS","Agence Nationale de la Recherche"],"pagination":["100890"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11287191"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["5(7)"],"pubmed_abstract":["Plant-specific transcriptional regulators called TELOMERE REPEAT BINDING proteins (TRBs) combine two DNA-binding domains, the GH1 domain, which binds to linker DNA and is shared with H1 histones, and the Myb/SANT domain, which specifically recognizes the telobox DNA-binding site motif. TRB1, TRB2, and TRB3 proteins recruit Polycomb group complex 2 (PRC2) to deposit H3K27me3 and JMJ14 to remove H3K4me3 at gene promoters containing telobox motifs to repress transcription. Here, we demonstrate that TRB4 and TRB5, two related paralogs belonging to a separate TRB clade conserved in spermatophytes, regulate the transcription of several hundred genes involved in developmental responses to environmental cues. TRB4 binds to several thousand sites in the genome, mainly at transcription start sites a"],"journal":["Plant communications"],"pubmed_title":["The TELOMERE REPEAT BINDING proteins TRB4 and TRB5 function as transcriptional activators of PRC2-controlled genes to regulate plant development."],"pmcid":["PMC11287191"],"funding_grant_id":["ANR-22-CE20-0001","4D-HEAT ANR-21-CE20-0036"],"pubmed_authors":["Le Goff S","Barneche F","Bourbousse C","Simon L","Amiard S","Feit L","Wolff L","Vanrobays E","Butter F","Tatout C","Probst AV","Loizeau L"],"additional_accession":[]},"is_claimable":false,"name":"The TELOMERE REPEAT BINDING proteins TRB4 and TRB5 function as transcriptional activators of PRC2-controlled genes to regulate plant development.","description":"Plant-specific transcriptional regulators called TELOMERE REPEAT BINDING proteins (TRBs) combine two DNA-binding domains, the GH1 domain, which binds to linker DNA and is shared with H1 histones, and the Myb/SANT domain, which specifically recognizes the telobox DNA-binding site motif. TRB1, TRB2, and TRB3 proteins recruit Polycomb group complex 2 (PRC2) to deposit H3K27me3 and JMJ14 to remove H3K4me3 at gene promoters containing telobox motifs to repress transcription. Here, we demonstrate that TRB4 and TRB5, two related paralogs belonging to a separate TRB clade conserved in spermatophytes, regulate the transcription of several hundred genes involved in developmental responses to environmental cues. TRB4 binds to several thousand sites in the genome, mainly at transcription start sites a","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jul","modification":"2026-06-03T00:18:40.467Z","creation":"2026-04-22T03:12:01.581Z"},"accession":"S-EPMC11287191","cross_references":{"pubmed":["38566416"],"doi":["10.1016/j.xplc.2024.100890"]}}