biostudies-literatureSudan SKNCI NIH HHSe2421846https://www.ebi.ac.uk/biostudies/studies/S-EPMC11287389biostudies-literatureUnknown7(7)<h4>Importance</h4>Epidemiologic data suggest an association of obesity with breast cancer (BC); however, obesity's contribution to early onset and risk of diagnosis with specific molecular subtypes by race is uncertain.<h4>Objective</h4>To examine the race-specific association of body mass index with early onset and diagnosis of specific molecular subtypes.<h4>Design, setting, and participants</h4>This retrospective cohort study included patients with BC diagnosed between October 1, 2017, and March 31, 2022, at 3 University of South Alabama Mitchell Cancer Institute clinics. Participants were also prospectively enrolled for serum leptin measurement.<h4>Main outcomes and measures</h4>The primary outcome was age at BC onset and specific subtype diagnosis. The secondary outcome was race-specJAMA network openObesity and Early-Onset Breast Cancer and Specific Molecular Subtype Diagnosis in Black and White Women: NIMHD Social Epigenomics Program.PMC11287389R01 CA231925Poosarla TSudan SKHolliday NPSharma ADavis WNelson CVikramdeo KSSingh APSingh KPSingh SDeshmukh SKProdduturvar PfalseObesity and Early-Onset Breast Cancer and Specific Molecular Subtype Diagnosis in Black and White Women: NIMHD Social Epigenomics Program.<h4>Importance</h4>Epidemiologic data suggest an association of obesity with breast cancer (BC); however, obesity's contribution to early onset and risk of diagnosis with specific molecular subtypes by race is uncertain.<h4>Objective</h4>To examine the race-specific association of body mass index with early onset and diagnosis of specific molecular subtypes.<h4>Design, setting, and participants</h4>This retrospective cohort study included patients with BC diagnosed between October 1, 2017, and March 31, 2022, at 3 University of South Alabama Mitchell Cancer Institute clinics. Participants were also prospectively enrolled for serum leptin measurement.<h4>Main outcomes and measures</h4>The primary outcome was age at BC onset and specific subtype diagnosis. The secondary outcome was race-spec2024-01-01T00:00:00Z2024 Jul2026-06-03T00:18:52.869Z2026-04-22T03:11:28.399ZS-EPMC112873893907381810.1001/jamanetworkopen.2024.21846