{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Frausing MHJP"],"funding":["The Netherlands Cardiovascular Research Initiative","Medtronic Trading"],"pagination":["1030-1039"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11287643"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["110(16)"],"pubmed_abstract":["<h4>Background</h4>We aimed to evaluate the association between atrial fibrillation (AF) burden, duration and number of episodes with healthcare utilisation and quality of life in patients with early paroxysmal AF without a history of AF.<h4>Methods</h4>In this observational cohort study, we included 417 patients with paroxysmal AF from the Reappraisal of Atrial Fibrillation: interaction between hyperCoagulability, Electrical remodelling and Vascular destabilisation in the progression of AF (RACE V) Study. Patients were monitored with an insertable cardiac monitor for 1 year. Outcomes collected were healthcare utilisation, and quality of life assessed using the Atrial Fibrillation Severity Scale and EuroQol EQ-5D-5L questionnaires.<h4>Results</h4>During 1 year of follow-up, 63 973 AF episodes were detected in 353 (85%) patients. The median AF burden was 0.7% (IQR 0.1-4.0%). AF ablation was performed more frequently in patients with intermediate-to-high AF burdens (>0.2%) (16.2% vs 5.9%, p=0.01) and longer AF episode duration (>1 hour) (15.8% vs 2.0%, p=0.01), whereas cardioversions were more frequent in patients with longer episode duration (>1 hour) (9.5% vs 0%, p=0.04) and intermediate (0.2-1.9%) (but not high) AF burdens (13.6% vs 4.2%, p=0.01). Patients with many episodes (>147) reported higher symptom severity (p=0.001). No differences in symptom severity nor in EQ-5D-5L scores according to AF burden or duration were observed.<h4>Conclusion</h4>In patients with early paroxysmal AF, higher AF burden and longer episode duration were associated with increased rates of healthcare utilisation but not with symptoms and quality of life. Patients with a higher number of episodes experienced more severe symptoms.<h4>Trial registration number</h4>NCT02726698."],"journal":["Heart (British Cardiac Society)"],"pubmed_title":["Healthcare utilisation and quality of life according to atrial fibrillation burden, episode frequency and duration."],"pmcid":["PMC11287643"],"funding_grant_id":["N/A","CVON 2014-9"],"pubmed_authors":["Van De Lande M","Tieleman RG","Linz D","Hemels MEW","Nielsen JC","De Melis M","Kronborg MB","Frausing MHJP","Rienstra M","Schotten U","Crijns HJGM","Van Gelder I"],"additional_accession":[]},"is_claimable":false,"name":"Healthcare utilisation and quality of life according to atrial fibrillation burden, episode frequency and duration.","description":"<h4>Background</h4>We aimed to evaluate the association between atrial fibrillation (AF) burden, duration and number of episodes with healthcare utilisation and quality of life in patients with early paroxysmal AF without a history of AF.<h4>Methods</h4>In this observational cohort study, we included 417 patients with paroxysmal AF from the Reappraisal of Atrial Fibrillation: interaction between hyperCoagulability, Electrical remodelling and Vascular destabilisation in the progression of AF (RACE V) Study. Patients were monitored with an insertable cardiac monitor for 1 year. Outcomes collected were healthcare utilisation, and quality of life assessed using the Atrial Fibrillation Severity Scale and EuroQol EQ-5D-5L questionnaires.<h4>Results</h4>During 1 year of follow-up, 63 973 AF episodes were detected in 353 (85%) patients. The median AF burden was 0.7% (IQR 0.1-4.0%). AF ablation was performed more frequently in patients with intermediate-to-high AF burdens (>0.2%) (16.2% vs 5.9%, p=0.01) and longer AF episode duration (>1 hour) (15.8% vs 2.0%, p=0.01), whereas cardioversions were more frequent in patients with longer episode duration (>1 hour) (9.5% vs 0%, p=0.04) and intermediate (0.2-1.9%) (but not high) AF burdens (13.6% vs 4.2%, p=0.01). Patients with many episodes (>147) reported higher symptom severity (p=0.001). No differences in symptom severity nor in EQ-5D-5L scores according to AF burden or duration were observed.<h4>Conclusion</h4>In patients with early paroxysmal AF, higher AF burden and longer episode duration were associated with increased rates of healthcare utilisation but not with symptoms and quality of life. Patients with a higher number of episodes experienced more severe symptoms.<h4>Trial registration number</h4>NCT02726698.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jul","modification":"2026-06-08T06:27:46.645Z","creation":"2026-06-08T03:14:21.533Z"},"accession":"S-EPMC11287643","cross_references":{"pubmed":["38944418"],"doi":["10.1136/heartjnl-2024-324016"]}}