{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Mannion ML"],"funding":["Versus Arthritis","PCORI","Manchester Biomedical Research Centre","Rheumatology Research Foundation","Childhood Arthritis and Rheumatology Research Alliance","National Institute for Health Research (NIHR)","U.S. Food and Drug Administration","National Institutes of Health","NIAMS NIH HHS","Purdue Pharma","Patient-Centered Outcomes Research Institute","NIH HHS"],"pagination":["1090-1098"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11288784"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["76(8)"],"pubmed_abstract":["<h4>Objective</h4>The objective of this study was to compare the effectiveness of a second tumor necrosis factor inhibitor (TNFi) versus a non-TNFi biologic following discontinuation of a TNFi for patients with polyarticular-course juvenile idiopathic arthritis (pJIA).<h4>Methods</h4>Using the Childhood Arthritis and Rheumatology Research Alliance Registry, patients with pJIA who started receiving a second biologic following a first TNFi were identified. Patients were required to have no active uveitis on the index date and a visit six months after the index date. Outcome measures included Clinical Juvenile Arthritis Disease Activity Score with a maximum of 10 active joints (cJADAS10), cJADAS10 inactive disease (ID; ≤2.5) and cJADAS10 minimal disease activity (MiDA; ≤5). Multiple imputatio"],"journal":["Arthritis care & research"],"pubmed_title":["Comparative Effectiveness of a Second Tumor Necrosis Factor Inhibitor Versus a Non-Tumor Necrosis Factor Biologic in the Treatment of Patients With Polyarticular-Course Juvenile Idiopathic Arthritis."],"pmcid":["PMC11288784"],"funding_grant_id":["K23 AR075874","Norman B Gaylis, MD Clinical Research Award","K23 AR081410","20747","NIHR203308","21755"],"pubmed_authors":["Aviran Dagan N","Taneja A","Orandi A","Shehab A","Rafko J","Ruth N","Dalrymple A","Riordan M","Woolnough L","Flanagan E","Nigrovic P","Todd C","Blakley M","McCurdy D","Kitcharoensakkul M","Verbsky J","Theisen A","Taber S","Nassi L","Hahn T","Levy D","Lapin B","Weiser P","Dedeoglu F","Figueroa C","Miller M","Manos C","Oberle E","Almutairi A","Shenoi S","Grim A","Matchett D","Vega-Fernandez P","Kienzle B","Henrickson M","Stringer E","Collinge J","Paller A","Waite H","White A","Correll C","Wong S","Tory H","Ciaglia K","Chang-Hoftman A","Santiago 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Patients were required to have no active uveitis on the index date and a visit six months after the index date. Outcome measures included Clinical Juvenile Arthritis Disease Activity Score with a maximum of 10 active joints (cJADAS10), cJADAS10 inactive disease (ID; ≤2.5) and cJADAS10 minimal disease activity (MiDA; ≤5). Multiple imputatio","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Aug","modification":"2026-03-16T06:44:12.047Z","creation":"2025-08-15T03:06:17.002Z"},"accession":"S-EPMC11288784","cross_references":{"pubmed":["38556945"],"doi":["10.1002/acr.25339"]}}