{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Naratadam GT"],"funding":["National Institute of Neurological Disorders and Stroke","NIDCR NIH HHS","NINDS NIH HHS","NCI NIH HHS","NIAMS NIH HHS","National Institute of General Medical Sciences","NIGMS NIH HHS","NIH HHS"],"pagination":["17543"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11289433"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(1)"],"pubmed_abstract":["This study investigated the time course of gene expression changes during the progression of persistent painful neuropathy caused by paclitaxel (PTX) in male and female mouse hindpaws and dorsal root ganglia (DRG). Bulk RNA-seq was used to examine these gene expression changes at 1, 16, and 31 days post-last PTX. At these time points, differentially expressed genes (DEGs) were predominantly related to the reduction or increase in epithelial, skin, bone, and muscle development and to angiogenesis, myelination, axonogenesis, and neurogenesis. These processes are accompanied by the regulation of DEGs related to the cytoskeleton, extracellular matrix organization, and cellular energy production. This gene plasticity during the progression of persistent painful neuropathy could be interpreted as a biological process linked to tissue regeneration/degeneration. In contrast, gene plasticity related to immune processes was minimal at 1-31 days after PTX. It was also noted that despite similarities in biological processes and pain chronicity between males and females, specific DEGs differed dramatically according to sex. The main conclusions of this study are that gene expression plasticity in hindpaw and DRG during PTX neuropathy progression similar to tissue regeneration and degeneration, minimally affects immune system processes and is heavily sex-dependent at the individual gene level."],"journal":["Scientific reports"],"pubmed_title":["Degenerative and regenerative peripheral processes are associated with persistent painful chemotherapy-induced neuropathies in males and females."],"pmcid":["PMC11289433"],"funding_grant_id":["R01 NS065926","R01 DE029187","R01 NS112263","R50 CA265339","NS102161","P30 CA054174","S10 OD021805","NS112263","S10 OD030311","S10 OD030432","UC2 AR082195","T32 GM113896","GM113896","R01 NS102161"],"pubmed_authors":["Naratadam GT","Akopian AN","Mecklenburg J","Zou Y","Lai Z","Shein SA","Tumanov AV","Price TJ"],"additional_accession":[]},"is_claimable":false,"name":"Degenerative and regenerative peripheral processes are associated with persistent painful chemotherapy-induced neuropathies in males and females.","description":"This study investigated the time course of gene expression changes during the progression of persistent painful neuropathy caused by paclitaxel (PTX) in male and female mouse hindpaws and dorsal root ganglia (DRG). Bulk RNA-seq was used to examine these gene expression changes at 1, 16, and 31 days post-last PTX. At these time points, differentially expressed genes (DEGs) were predominantly related to the reduction or increase in epithelial, skin, bone, and muscle development and to angiogenesis, myelination, axonogenesis, and neurogenesis. These processes are accompanied by the regulation of DEGs related to the cytoskeleton, extracellular matrix organization, and cellular energy production. This gene plasticity during the progression of persistent painful neuropathy could be interpreted as a biological process linked to tissue regeneration/degeneration. In contrast, gene plasticity related to immune processes was minimal at 1-31 days after PTX. It was also noted that despite similarities in biological processes and pain chronicity between males and females, specific DEGs differed dramatically according to sex. The main conclusions of this study are that gene expression plasticity in hindpaw and DRG during PTX neuropathy progression similar to tissue regeneration and degeneration, minimally affects immune system processes and is heavily sex-dependent at the individual gene level.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jul","modification":"2026-06-01T16:19:57.65Z","creation":"2025-04-06T13:47:24.327Z"},"accession":"S-EPMC11289433","cross_references":{"pubmed":["39080341"],"doi":["10.1038/s41598-024-68485-6"]}}