{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lukoszek R"],"funding":["Cancer Research UK","European Research Council","Medical Research Council","Royal Society","Wellcome Trust"],"pagination":["114405"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11290353"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["43(7)"],"pubmed_abstract":["The RNA cap methyltransferase CMTR1 methylates the first transcribed nucleotide of RNA polymerase II transcripts, impacting gene expression mechanisms, including during innate immune responses. Using mass spectrometry, we identify a multiply phosphorylated region of CMTR1 (phospho-patch [P-Patch]), which is a substrate for the kinase CK2 (casein kinase II). CMTR1 phosphorylation alters intramolecular interactions, increases recruitment to RNA polymerase II, and promotes RNA cap methylation. P-Patch phosphorylation occurs during the G1 phase of the cell cycle, recruiting CMTR1 to RNA polymerase II during a period of rapid transcription and RNA cap formation. CMTR1 phosphorylation is required for the expression of specific RNAs, including ribosomal protein gene transcripts, and promotes cell"],"journal":["Cell reports"],"pubmed_title":["CK2 phosphorylation of CMTR1 promotes RNA cap formation and influenza virus infection."],"pmcid":["PMC11290353"],"funding_grant_id":["769080","097462/Z/11/Z","WRM\\u2216R1\\u2216180008","219416/A/19/Z","097945/Z/11/Z","CTRQQR-2021\\u2216100006","A17196 / A31287","MR/K024213/1"],"pubmed_authors":["Liang S","Brett NJM","Lukoszek R","Pirillo C","Inesta-Vaquera F","Cowling VH","Roberts EW","Hughes DJ","Hepburn LA"],"additional_accession":[]},"is_claimable":false,"name":"CK2 phosphorylation of CMTR1 promotes RNA cap formation and influenza virus infection.","description":"The RNA cap methyltransferase CMTR1 methylates the first transcribed nucleotide of RNA polymerase II transcripts, impacting gene expression mechanisms, including during innate immune responses. Using mass spectrometry, we identify a multiply phosphorylated region of CMTR1 (phospho-patch [P-Patch]), which is a substrate for the kinase CK2 (casein kinase II). CMTR1 phosphorylation alters intramolecular interactions, increases recruitment to RNA polymerase II, and promotes RNA cap methylation. P-Patch phosphorylation occurs during the G1 phase of the cell cycle, recruiting CMTR1 to RNA polymerase II during a period of rapid transcription and RNA cap formation. CMTR1 phosphorylation is required for the expression of specific RNAs, including ribosomal protein gene transcripts, and promotes cell","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jul","modification":"2026-06-01T16:20:02.903Z","creation":"2025-04-19T07:05:25.057Z"},"accession":"S-EPMC11290353","cross_references":{"pubmed":["38923463"],"doi":["10.1016/j.celrep.2024.114405"]}}